This entry represents the RNA recognition motif (RRM) of snRNP35 (also known as U11/U12-35K), which is one of the components of the U11/U12 snRNP, a spliceosome required for splicing U12-type nuclear pre-mRNA introns [, ]. U11/U12-35K is highly conserved among bilateria and plants, but is lacking in some organisms, such as Saccharomyces cerevisiae and Caenorhabditis elegans. Moreover, U11/U12-35K shows significant sequence similarity to U1 snRNP-specific 70kDa protein (U1-70K or snRNP70) []. U11/U12-35K contains a conserved RNA recognition motif (RRM), followed by an adjacent glycine-rich region, and an Arg-Asp and Arg-Glu dipeptide repeat-rich domain, making U11/U12-35K a possible functional analogue of U1-70K. It may facilitate 5' splice site recognition in the minor spliceosome and play a role in exon bridging, interacting with components of the major spliceosome bound to the pyrimidine tract of an upstream U2-type intron [, ].
