Sorting nexins (SNXs) or phox homology (PX) domain containing proteins are central regulators of cell trafficking and signalling []. Some PX domain proteins, namely SNX13, SNX14, and SNX25, also possess a regulator of G protein-coupled receptor signaling (RGS) domain and two unique PX-associated domains. SNX25 is a regulator of transforming growth factor (TGF-) signaling, binding to and promoting the lysosomal trafficking and degradation of TGF-receptors []. The SNX25 PX domain has sequence alterations and may not be able to coordinate phosphoinositide-binding [].
This entry represents the PX domain of SNX25.Sorting nexins (SNXs) or phox homology (PX) domain containing proteins are central regulators of cell trafficking and signalling []. Some PX domain proteins, namely SNX13, SNX14, and SNX25, also possess a regulator of G protein-coupled receptor signaling (RGS) domain and two unique PX-associated domains. SNX25 is a regulator of transforming growth factor (TGF-) signaling, binding to and promoting the lysosomal trafficking and degradation of TGF-receptors []. The SNX25 PX domain has sequence alterations and may not be able to coordinate phosphoinositide-binding [].
