This group represents a SPARC-like (Secreted Protein Acidic and Rich in Cysteine) protein 1 (SPARCL1; also known as Hevin). SPARCL1 is a secreted glycoprotein, belonging to SPARC family of matricellular proteins []. SPARCL1 is downregulated in various tumours and may have a tumor-suppressor function [, ].