Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex, which is implicated in several essential outer kinetochore functions, including microtubule binding and control the spindle assembly checkpoint [, ].
Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex, which is implicated in several essential outer kinetochore functions, including microtubule binding and control the spindle assembly checkpoint [, ].The Ndc80 complex appears to be a long rod with globular 'heads'. Ndc80 and Nuf2 contribute to one head and to the intervening shaft; Spc24 and Spc25 complete the shaft and contribute to the other head. Spc24 and Spc25 fold tightly together. TheC-terminal globular domains of Spc24 and Spc25 form the 'inner' head, which faces the centromere [].
This entry includes SPC24 homologue, MUN (MERISTEM UNSTRUCTURED), from Arabidopsis. SPC24 is part of the outer kinetochore complex NDC80. In Arabidopsis, MUN interacts with components of the NDC80 complex and is required for chromosome segregation to ensure proper cell division [].
The Ndc80 complex is a conserved outer kinetochore protein complex consisting of Ndc80 (Hec1), Nuf2, Spc24 and Spc25. The Ndc80 complex is required for chromosome segregation and spindle checkpoint activity [, , ].
Monopolar spindle protein 2 (Mps2) is a fungal transmembrane protein localised to the spindle pole body (SPB) []. It is required for the insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication [, ]. The interaction between Mps2 and Spc24 may contribute to the localisation of Spc24 and other kinetochore components to the inner plaque of the SPB [].
The Ndc80 complex is a conserved outer kinetochore protein complex consisting of Ndc80 (Hec1), Nuf2, Spc24 and Spc25. The Ndc80 complex is required for chromosome segregation and spindle checkpoint activity [, , ].This entry represents the C-terminal domain of Spc25 [].
