Protein sprouty homologue 4 (SPRY4) belongs to the sprouty family, whose members are inhibitors of the Ras-ERK pathway downstream of various receptor tyrosine kinases. SPRY4 is a feedback negative regulator of FGFs-induced ERK1/2 signalling. It suppresses Ras-independent ERK activation by binding to Raf1 []. It may function as a tumour suppressor in endometrial adenocarcinoma []. It plays a critical role in developing inflammatory Th17 cells in Th17 cell-driven autoimmune diseases [].
