This entry represents the cwf21 domain of SRRM2 and similar proteins from vertebrates. This domain is involved in mRNA splicing. It binds directly to the spliceosomal protein Prp8.Serine/arginine repetitive matrix protein 2 (SRRM2) is also called 300 kDa nuclear matrix antigen, serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa, SR-related nuclear matrix protein of 300 kDa, or Tax-responsive enhancer element-binding protein 803 (TaxREB803). It is required for pre-mRNA splicing as component of the spliceosome. It contains a cwf21 domain at the N-terminal [, , , , , , ].
This family consists of serine/arginine repetitive matrix proteins (SRRM), including SRRM2, SRRM3, and SRRM4, which are found primarily in eukaryotes. They function as RNA splicing factors that regulate alternative splicing and are components of the spliceosome. SRRM2 is required for pre-mRNA splicing and is a component of the minor spliceosome, which splices U12-type introns. SRRM3 and SRRM4 regulate the inclusion of microexons in mRNA transcripts and are essential for neural cell differentiation, motor coordination, and nervous system development [, , , , , , ]. In cortical neurons, SRRM3 and SRRM4 act redundantly to regulate alternative splicing events, such as the inactivation of the transcriptional repressor REST []. SRRM3 also mediates microexon inclusion in pancreatic islets, regulating insulin and glucagon secretion [].
