This entry represents the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain of STARD10 (also known as CGI-52, PTCP-like, and SDCCAG28). STARD10 binds phophatidylcholine and phosphatidylethanolamine. It may function in the liver in the export of phospholipids into bile []. It is concentrated in the sperm flagellum, and may play a role in energy metabolism. In the mammary gland it may participate in the enrichment of lipids in milk, and be a potential marker of differentiation. Its expression is induced in this gland during gestation and lactation []. It is overexpressed in mammary tumours from Neu/ErbB2 transgenic mice, in several breast carcinoma cell lines, and in 35% of primary human breast cancers, and may cooperate with c-erbB receptor signaling in breast oncogenesis []. It is a potential marker of disease outcome in breast cancer; loss of STARD10 expression in breast cancer strongly predicts an aggressive disease course []. The lipid transfer activityof STRAD10 is downregulated by phosphorylation of its Ser284 by CK2 (casein kinase 2) [].
