Stonin-1, also known as stoned B-like factor, belongs to the stonin family. Its function is not clear.Stonin family members are conserved clathrin adaptor complex AP-2mu-related factors that may act as cargo-specific sorting adaptors in endocytosis. They are conserved from C. elegans to humans, but are not found in prokaryotes or yeasts. Their protein structure consists of an N-terminal proline- and serine-rich domain, a central stonin homology domain (SHD), and a C-terminal Mu homology domain that may adopt a conformation similar to the C-terminal sorting signal binding domain of AP-2mu (C-mu2) [].
