STAGA complex 65 subunit gamma (SUPT7L) is a component of the structural core of the STAGA transcription coactivator-histone acetyltransferase (HAT) complex, which is composed of at least SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12 and TAF9. This complex, the TAF8-TAF10 histone fold (HF)-containing protein complex and the SMAT complex are important regulators of the composition of different TFIID and/or STAGA/TFTC complexes in the nucleus and consequently may play a role in gene regulation [, ].