This is an acidic sequence segment domain found in the splicing factor SYNCRIP (hnRNP Q) which is involved in viral replication, neural morphogenesis, modulation of circadian oscillation and the regulation of the cytidine deaminase APOBEC1. This domain is a self-folding globular domain with an all α-helix architecture with negatively charged surface areas. Additionally it contains a large hydrophobic cavity and a positively charged surface area as potential epitopes for inter-molecular interactions [].
This entry represents the RNA recognition motif 1 (RRM1) of heterogeneous nuclear ribonucleoprotein Q (hnRNP Q).hnRNP Q (also known as NSAP1 or GRY-RBP) is a RNA-binding protein found in the spliceosome complex and the apobec-1 editosome [, ]. It acts as an interaction partner of a multifunctional protein required for viral replication, and is implicated in the regulation of specific mRNA transport []. hnRNP Q has also been identified as SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein), a dual functional protein participating in both viral RNA replication and translation [, ]. As a synaptotagmin-binding protein, hnRNP Q plays a putative role in organelle-based mRNA transport along the cytoskeleton []. Moreover, hnRNP Q has been found in protein complexes involved in translationally coupled mRNA turnover and mRNA splicing. It functions as a wild-type survival motor neuron (SMN)-binding protein that may participate in pre-mRNA splicing and modulate mRNA transport along microtubuli [].hnRNP Q contains an acidic auxiliary N-terminal region, followed by two well-defined and one degenerated RNA recognition motifs (RRMs), and a C-terminal RGG motif; hnRNP Q binds RNA through its RRM domains [].
This entry representsthe RNA recognition motif 2 (RRM2) of heterogeneous nuclear ribonucleoprotein Q (hnRNP Q).hnRNP Q (also known as NSAP1 or GRY-RBP) is a RNA-binding protein found in the spliceosome complex and the apobec-1 editosome [, ]. It acts as an interaction partner of a multifunctional protein required for viral replication, and is implicated in the regulation of specific mRNA transport []. hnRNP Q has also been identified as SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein), a dual functional protein participating in both viral RNA replication and translation [, ]. As a synaptotagmin-binding protein, hnRNP Q plays a putative role in organelle-based mRNA transport along the cytoskeleton []. Moreover, hnRNP Q has been found in protein complexes involved in translationally coupled mRNA turnover and mRNA splicing. It functions as a wild-type survival motor neuron (SMN)-binding protein that may participate in pre-mRNA splicing and modulate mRNA transport along microtubuli [].hnRNP Q contains an acidic auxiliary N-terminal region, followed by two well-defined and one degenerated RNA recognition motifs (RRMs), and a C-terminal RGG motif; hnRNP Q binds RNA through its RRM domains [].
