Synaptotagmin-11 (SYT11) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains (known as C2A and C2B domains). Most of the synaptotagmins have a unique N-terminal domain (transmembrane region) that is involved in membrane anchoring or specific ligand binding. The SYT11 gene is located on a major susceptibility locus of familial schizophrenia []. The STY11 loci has also been linked to Parkinson's disease (PD) []. Parkin, a ubiquitin ligase, binds to the C2A and C2B domains of SYT11 resulting in the polyubiquitination of SYT11 [].
