Synaptotagmin-5 (SYT5) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains. Most of the synaptotagmins have a unique N-terminal domain that is involved in membrane anchoring or specific ligand binding. SYT5 is involved in the Ca2+-dependent stimulation of insulin exocytosis []. SYT5 is also known as synaptotagmin IX (SYT9) in rodents. In PC12 (phaeochromocytoma) cells, it regulates Ca2+-dependent secretion [].
