Synaptotagmin-8 (Syt8) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains (known as C2A and C2B domains). Most of the synaptotagmins have a unique N-terminal domain that is involved in membrane anchoring or specific ligand binding. Mammals contain 16 synaptotagmins; eight of these bind Ca2+ via their C2-domains (Syt1-Syt3, Syt5-7, Syt9, and Syt10), whereas the other eight, including Syt8, do not [].Syt8 is expressed in neurons, neuroendocrine and endocrine cells []. It is involved in insulin secretion []and may function in acrosomal exocytosis [].
