This is a domain found in TASOR proteins, a key component of the HUSH complex, a vertebrate-specific multiprotein complex that mediates epigenetic repression of both exogenous and endogenous genetic elements [, , ]. The HUSH complex regulates H3K9me3 deposition by promoting recruitment of SETDB1 and also recruits MORC2 to compact chromatin [, ]. TASOR is crucial in early embryonic development []and contains a catalytically-inactive PARP domain, necessary for epigenetic regulation of target elements.This entry represents an ��/�� domain found towards the C terminus of TASOR and TASOR2 which consist of four ��-sheets and short ��-helices.
This is a domain found in TASOR proteins, a key component of the HUSH complex, a vertebrate-specific multiprotein complex that mediates epigenetic repression of both exogenous and endogenous genetic elements [, , ]. The HUSH complex regulates H3K9me3 deposition by promoting recruitment of SETDB1 and also recruits MORC2 to compact chromatin [, ]. TASOR is crucial in early embryonic development []and contains a catalytically-inactive PARP domain, necessary for epigenetic regulation of target elements. This entry represents a PIN domain found towards the C terminus of TASOR and TASOR2 and shares detectable similarity to the PIN domain of SMG5.
