TBC1D7 is part of the TSC1-TSC2-TBC1D7 complex that serves as a negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to environmental cues []. TBC1D7 helps to stabilize the TSC1-TSC2 complex through its direct interaction with TSC1. Homozygous inactivation of TBC1D7 causes intellectual disability and megaencephaly [].
TBC1D7 is part of the TSC1-TSC2-TBC1D7 complex that serves as a negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to environmental cues []. TBC1D7 helps to stabilize the TSC1-TSC2 complex through its direct interaction with TSC1. Homozygous inactivation of TBC1D7 causes intellectual disability and megaencephaly [].This superfamily represents the second out of three domains found in TBC1D7. Structurally, this domain consists of 4 alpha helices.
