This entry includes protein 1 found in association with tubulins epsilon and delta complex. This complex is required for centriole maintenance and it has been demonstrated that it is a component of several ciliary structures. It acts as a positive regulator of ciliary hedgehog signalling which plays key roles in embryonic development and in cancers []. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerising microbial metabolite Chivosazole F [].
This entry represents a domain found in TEDC1 (Tubulin epsilon and delta complex protein 1). TEDC is a complex required for centriole maintenance and it is a component of several ciliary structures. It acts as a positive regulator of hedgehog signalling, which play key roles in embryonic development and in cancers []. Additionally, this protein may play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerising microbial metabolite Chivosazole F [].
