Tankyrase-1 (TANK1) is a poly-ADP-ribosyltransferase involved in various processes, including the Wnt signaling pathway, telomere length regulation and vesicle trafficking [, , , ]. In telomere length regulation and sister chromatid separation, it binds to the N terminus of telomeric TERF1 via the ANK repeats []. It binds to the RXXPDG motif in the carboxy terminal domain of NuMA, which play an essential role in mitotic spindle assembly []. It also binds to the RXXPDG motif in the cytoplasmic tail of IRAP, which is an integral membrane protein that localises to GLUT4 storage vesicles that are found in insulin responsive tissues [].
