This entry represents a CXC domain found in proteins such as Tesmin []and TSO1 []. These proteins have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C.
This entry represents the lin-54 family of proteins. Members include lin-54 and tesmin. Lin-54 is a component of the DREAM (MuvB/DRM) complex, which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes [, ]. Tesmin may have a role in spermatogenesis [, ].
The following proteins of the tesmin/TSO1 family contain two cysteines-richrepeats with the consensus C-X-C-X(4)-C-X(3)-Y-C-X-C-X(6)-C-X(3)-C-X-C-X(2)-Cseparated by a region of variable length containing the short conservedsequence R-N-P-X-A-F-X-P-K:Animal tesmin or MTL5, originally identified by its specific expression in testes, but subsequently it was also detected at specific stages of ovary development.Animal tesmin-like (tesl) or LIN54.Drosophila melanogaster tombola (tomb), a meiotic arrest protein which is expressed specifically in testis.Arabidopsis thaliana TSO1, 'tso' means 'ugly' in Chinese and refers to the appearance of tso1 mutant flowers.Arabidopsis thaliana TSO1-like 1 and 2 (SOL1 and SOL2).Legume Cysteine-rich Polycomb-like Protein 1 (CPP1), a DNA-binding protein acting as a negative regulator of the leghemoglobin gene.This domain has been named the CRC domain (C1-RNPXAFXPK-C2). It binds zinc andis able to bind DNA [, , , , ].The CRC domain shows some similarity to the CXC domain found in the E(z)-typeof Polycomb group proteins []. However, a clear distinctioncan be made, since the CXC domain lacks the RNPXAFXPK motif.
