Testis-expressed protein 11 (TEX11), also known as ZIP4H, is a regulator of crossing-over during meiosis. It is involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers [, ]. Mutations in the TEX11 gene cause Spermatogenic failure, X-linked, 2 (SPGFX2), an infertility disorder caused by spermatogenesis defects [].
This entry includes a group of meiosis specific proteins, including Spo22 from budding yeasts, ZIP4 from plants and TEX11 from mammals. They play an important role in normal crossover formation and meiotic chromosome segregation [, , ]. Impairment of these functions results in meiosis I (MI) segregation defect [].
This entry represents the Protein SPO16 homologue (SPO16, also known as Synaptonemal complex reinforcing element SCRE), including the mammalian orthologue of budding yeast Spo16. It plays a key role in reinforcing the integrity of the central element of the synaptonemal complex (SC), resulting in the SC stabilization which ensures the progression of meiotic prophase I in male and female germ cells [. It promotes homologous recombination and crossing-over in meiotic prophase I via its association with SHOC1 []. It is also required for the localization of TEX11 and MSH4 to recombination intermediates [].
