Thyroid hormone receptor-associated protein 3 (also known as TRAP150 or THRAP3) is associated with the transcription regulatory complex TRAP/Mediator, and is a component of the spliceosome []. It is involved in pre-mRNA splicing and mRNA decay [, ]. It also promotes resistance to DNA-damaging agents [].
Helicase with zinc finger domain 2 (HELZ2) is a helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA []. It interacts with THRAP3 (thyroid hormone receptor-associated protein3), a putative component of the Mediator complex that plays a role in adipocyte differentiation [].
