TRAF-interacting protein with a forkhead-associated domain (TIFA), also called T2BP, is an adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and c-Jun amino-terminal kinase (JNK) []. TIFA has been shown to induce the oligomerization and polyubiquitination of TRAF6, which in turn activates transforming growth factor-activated kinase (TAK1) and IkappaB kinase (IKK) []. TIFA contains a phosphothreonine and phosphoserine-binding FHA domain []and a consensus TRAF6-binding motif [].
