TERF1-interacting nuclear factor 2, also known as TIN2, is a component of the shelterin complex (telosome), which is involved in the protection and maintenance of telomeres [, , ]. TINF2 plays a role in shelterin complex assembly []. In humans, one of its isoforms may have an additional role in tethering telomeres to the nuclear matrix [].
This entry represents the N-terminal domain of TERF1-interacting nuclear factor 2 (TINF2). It is a component of the shelterin complex (telosome), which is involved in the protection and maintenance of telomeres [, , ]. TINF2 plays a role in shelterin complex assembly []. In humans, one of its isoforms may have an additional role in tethering telomeres to the nuclear matrix [].
