The EXPERA (EXPanded EBP superfamilly) domain is conserved among the followingprotein families:Vertebrate TM6SF1 (Transmembrane 6 Superfamily Member 1).Vertebrate TM6SF2 (Transmembrane 6 Superfamily Member 2).Eukaryotic MAC30 (Meningioma-associated protein 30) also known as TMEM97(Transmembrane protein 97), mainly localized in the endoplasmic reticulum(ER).Eukaryotic EBP (Emopamil binding protein), an enzyme with a D8, D7 sterolisomerase activity that catalyzes the transposition of a double bond fromC8=C9 to C7=C8 in the sterol B-ring.The EXPERA domain contains four transmembrane regions and is likely to possessa sterol isomerase catalytic activity [].
