This entry includes human TMEM9/TMEM9B and their homologues. TMEM9 is a transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking []. It acts as a Wnt signaling amplifier that hyperactivates Wnt signaling for liver regeneration and tumorigenesis via lysosomal degradation of APC []. TMEM9B has been shown to regulate the activity of inflammatory signaling pathways [].
