The entry includes proteins with ubiquitin-like domains. Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1) is involved in the sterol-regulated ubiquitination and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. TMUB1 and SPFH2 associate with mammalian gp78, the membrane-bound ubiquitin ligase in the ERAD pathway [].
