Tumor necrosis factor receptor superfamily member 26 (TNFRSF26), also known as tumor necrosis factor receptor homologue 3 (TNFRH3) or TNFRSF24, is predominantly expressed in embryos and lymphoid cell types, along with its closely related TNFRSF22 and TNFRSF23 orthologues, and is developmentally regulated. These three TNFSFRs genes are present in the mouse and rat, but absent in humans []. Unlike TNFRSF22/23, TNFRSF26 does not serve as a TRAIL decoy receptor; it remains an orphan receptor [].This entry represents the N-terminal domain of TNFRSF26 and the TNFRSF22 and TNFRSF23 orthologues. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].
