This entry represents the second TPR domain found in Transportin-3 (TNPO3) from animals, as well as orthologues MTR10 and uncharacterised protein YNR7 from yeast and MOS14 from plant. This entry also includes Importin-13 (IPO3) from animals. This domain is involved in the binding to the globular Ran protein in TNOP3 []. In IPO13, this domain is involved in the protein interaction with Ubc9 for nuclear import []and with eIF1A for nuclear import [].These proteins are involved in transport of target proteins into the nucleus. TNPO3 mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognising phosphorylated SR domains [, ].
This entry represents the third TPR domain found in Transportin-3 (TNPO3) from animals, as well as orthologues MTR10 and uncharacterised protein YNR7 from yeast and MOS14 from plants. This entry also includes Importin-13 (IPO3) from animals. This domain is part of TPR structure that binds proteins for nuclear transport [, ].These proteins are involved in transport of target proteins into the nucleus. TNPO3 mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognising phosphorylated SR domains [, ].
This entry represents the third TPR domain found in Transportin-3 (TNPO3) from animals, as well as orthologues MTR10and uncharacterised protein YNR7 from yeast and MOS14 from plants. This entry also includes Importin-13 (IPO3) from animals. This domain interacts with the RS region of the ASF protein for nuclear transport [].These proteins are involved in transport of target proteins into the nucleus. TNPO3 mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognising phosphorylated SR domains [, ].
