This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C terminus of TRIM62. TRIM62 is a RING finger E3 ubiquitin ligase, also called DEAR1 (ductal epithelium associated RING chromosome 1) []. It is involved in the morphogenesis of the mammary gland; loss of TRIM62 gene expression in breast is associated with increased risk of recurrence in early-onset breast cancer and thus, making TRIM62 a predictive biomarker [, ]. Non-small cell lung cancer lesions show a step-wise loss of TRIM62 levels during disease progression, indicating that it may play a role in the evolution of lung cancer []. Decreased levels of TRIM62 also represent an independent adverse prognostic factor in acute myeloid leukemia [].
