This entry includes a group of E3 ubiquitin-protein ligases, including HECTD1/TRIP12 from humans, Ufd4 from budding yeasts and UPL3/4 from Arabidopsis. TRIP12 is involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair [, ]. HECTD1 regulates intracellular localization and secretion of Hsp90 and is essential for the correct development of the cranial neural folds and neural tube closure [, ].
This entry represents TRADD (or tumour necrosis factor receptor type 1-associated DEATH domain protein). TRADD interacts with the cytoplasmic domain of activated TNFRSF1A/TNFR1, which in turn enables it to interact with FADD. Overexpression of TRADD results in apoptosis and activation of NF-kappa-B []. TRADD shuttles from the cytoplasm into the nucleus. The nuclear form of TRADD is a tumour suppressor, which by interacting with TRIP12 disrupts its complex with isoform p19ARF/ARF of CDKN2A, preventing ubiquitination and degradation [].
