TrmO (also known as TsaA or YaeB) is a RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. It has a unique single-sheeted β-barrel structure and represent a new category of AdoMet-dependent methyltransferases [].
TrmO (also known as TsaA or YaeB) is a RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. It has a unique single-sheeted β-barrel structure and represent a new category of AdoMet-dependent methyltransferases [].
TrmO (also known as TsaA or YaeB) is a RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. It has a unique single-sheeted β-barrel structure and represent a new category of AdoMet-dependent methyltransferases [].The following uncharacterised proteins have been shown to be evolutionary related and to contain a TrmO-like beta barrel structural domain domain:Agrobacterium tumefaciens Ti plasmid protein virR.Pseudomonas aeruginosa protein rcsF.Archaeoglobus fulgidus hypothetical protein AF0241.Archaeoglobus fulgidus hypothetical protein AF0433.Methanococcus jannaschii hypothetical protein MJ1583.Methanobacterium thermoautotrophicum hypothetical protein MTH1797.Mammalian Nef-associated protein 1 (NAP1). The crystal structure of Haemophilus influenzae TrmO has been solved. In addition to the N-terminal β-barrel methyltransferase domain it has a C-terminal domain containing the conserved sequence motif DPRxxY [].
TrmO (also known as TsaA or YaeB) is a RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. It has a unique single-sheeted β-barrel structure and represent a new category of AdoMet-dependent methyltransferases [].The crystal structure of Haemophilus influenzae YaeB has been solved. In addition to the N-terminal β-barrel methyltransferase domain it has a C-terminal domain containing the conserved sequence motif DPRxxY []. This superfamily describes the N-terminal domain.
