The TRPM subfamily of mammalian TRP channels includes TRPM2, which has both Ca(2+)-permeable nonselective ion channel functionality and enzymatic ADP-ribose (ADPr) hydrolase activity []. TRPM2 channels are embedded in the plasma membrane and/or lysosomal compartments and are activated in a synergistic fashion by intracellular ADP-ribose (ADPr) and Ca(2+) []. They are also activated by oxidative stress, and confer susceptibility to cell death []. TRPM2 proteins are widely expressed in a range of tissues, including the brain, immune system, endocrine cells, and endothelia. They are involved in a variety of functions, including cytokine production, insulin release, cell motility and cell death [].
