This entry represents ubiquitin carboxyl-terminal hydrolase 14 (UBP14) and its homologues, such as Ubp6 from fungi and Ubp6/7 from Arabidopsis. They are ubiquitin-specific proteases responsible for disassembling ubiquitin chains at the proteasome, cleaving ubiquitin precursors, and editing ubiquitin side chains []. It has been shown that an N-terminal ubiquitin-like (UBL) domain of USP14 associates with the base of the 26S proteasome and the interaction of USP14 with the proteasome activates the catalytic activity of USP14 [, ]. It has also be shown that Ubp6 has both deubiquitinating activity and proteasome-inhibitory activity [].
