Ubiquitin-specific peptidase 51 (USP51, MEROPS identifier C19.065) is a de-ubiquitinating enzyme that has been shown to release ubiquitin from protein conjugates. It specifically deubiquitinates Lys-14 (H2AK13Ub) and Lys-16 (H2AK15Ub) of histone H2A, thus regulating the DNA damage response at double-strand breaks (DSBs). It is also involved in the assembly/disassembly of of TP53BP1 and BRCA1 [].
