This entry includes E3 ubiquitin-protein ligase Pep5 (also known as vacuolar protein sorting-associated protein 11, Vps11) from fungi, and its homologues from plants and animals. Pep5 is a peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis []. It is also identified as an E3 ubiquitin ligase that regulates histone protein levels in Saccharomyces cerevisiae []. Human Vps11 may play a role in vesicle-mediated protein trafficking [].
This entry represents a domain found in the vacuolar sorting protein Vps39 and transforming growth factor beta receptor-associated protein Trap1. Vps39, a component of the C-Vps complex, is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole [, ]. In Saccharomyces cerevisiae (Baker's yeast), Vps39 has been shown to stimulate nucleotide exchange []. Trap1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling [, ]. The precise function of this domain has not been characterised In Vps39 this domain is involved in localisation and in mediating the interactions with Vps11 [].
