This entry represents Vacuolar protein sorting-associated 29 (Vps29) from animals, yeasts and plants. Vps29 is an essential component of the retromer complex, a conserved complex required in endosome-to-Golgi retrograde transport [].
This entry represents vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes.Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [, ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease []. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid [].
Members of this largely uncharacterised family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11, and a family of uncharacterised archaeal putative phosphoesterases. In this family, the His residue in GNHD portion of the motif is not conserved. The member MJ0936, one of two from Methanocaldococcus jannaschii (Methanococcus jannaschii), was shown []to act on model phosphodiesterase substrates; a divalent cation was required. This entry also represents Vps29 which is part of the retromer complex in yeast [].This entry also includes vacuolar protein sorting-associated protein 29 (vps29), which is an essential component of the retromer complex, a conserved complex required in endosome-to-Golgi retrograde transport [].
This superfamily represents the α-helical C-terminal domain found in vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes.Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [, ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease []. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid [].
