WDFY1 is a novel single FYVE domain containing protein that binds phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) with high specificity over other phosphoinositides. WDFY1 to early endosomes requires an intact FYVE domain and is inhibited by wortmannin, a PI3-kinase inhibitor. In addition to FYVE domain, WDFY1 harbours multiple WD-40 repeats. This entry represent the FYVE domain of WDFY1 [, ].
This entry represents a group of WD repeat and FYVE domain-containing proteins, including WDFY1 and WDFY2. WDFY1 mediates TLR3/4 signalling by recruiting TRIF []. WDFY2, also known as Prof (propeller-FYVE protein), is involved in endocytosis [].
