This family includes WD repeat-containing protein 7 and WD repeat-containing protein 72 (WDR7/72). The function of WDR7 is currently unknown.WD repeat-containing protein 72 (WDR72) plays a major role in the formation of tooth enamel, particularly during the maturation phase of amelogenesis, where it is essential for normal enamel matrix formation and the clearance of enamel proteins [, ]. WDR72 may also be involved in the localisation of the calcium transporter SLC24A4 to the ameloblast cell membrane. These proteins share a distinct domain architecture comprising one or two ��-propellers followed by an ��-solenoid domain , an evolutionarily conserved structure common among proteins that form membrane coat complexes, dating back to the early eukaryotic endomembrane system [].
This entry represents an ��-solenoid domain found in WDR72. This entry also includes WDR7, whose function is currently unknown.WD repeat-containing protein 72 (WDR72) plays a major role in the formation of tooth enamel, particularly during the maturation phase of amelogenesis, where it is essential for normal enamel matrix formation and the clearance of enamel proteins [, ]. WDR72 may also be involved in the localisation of the calcium transporter SLC24A4 to the ameloblast cell membrane. These proteins share a distinct domain architecture comprising one or two ��-propellers followed by an ��-solenoid domain , an evolutionarily conserved structure common among proteins that form membrane coat complexes, dating back to the early eukaryotic endomembrane system [].
