YY1-associated factor 2 (YAF2) binds to MYC and MYCN, inhibiting MYC-mediated transactivation and enhances MYCN-dependent transcriptional activation [, ]. It interacts with YY1, which is down-regulated at the protein level during myogenic differentiation, enhancing its degradation by calpain 2 []. It is a component of the E2F6.com-1 complex in G0 phase of the cell cycle []. YAF2 contains a RanBP2-type zinc finger.
Proteins included in this entry have an N-terminal RanBP2-type zinc finger and a Yaf2/RYBP C-terminal binding motif. Proteins with these regions include Yaf2 and RYBP proteins, which are homologous parts of the PRC1 complex [].RYBP is a zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosisis []. RYBP also binds ubiquitin and Cbx proteins via the C-terminal docking module [, ]. RYBP is natively unstructured until it binds to the C-terminal region of the Polycomb protein Ring1B or to DNA []. Yaf2 binds to MYC and inhibits MYC-mediated transactivation [].
This motif is found in the C-terminal region of the Yaf2 and RYBP proteins, which are homologous parts of the PRC1 complex [].RYBP is a zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosisis []. RYBP also binds ubiquitin and Cbx proteins via the C-terminal docking module [, ]. RYBP is natively unstructured until it binds to the C-terminal region of the Polycomb protein Ring1B or to DNA []. Yaf2 binds to MYC and inhibits MYC-mediated transactivation [].
