In mice, MEIOC is required for meiosis completion in both male and female germ cells []. It interacts with YTHDC2 and maintains an extended meiotic prophase I in mice []. In humans, it is encoded for on the chromosomal position C17orf104.
This entry represents the 3'-5' RNA helicase YTHDC2 (YTH domain containing 2) from mammals and related proteins. Proteins in this family belong to the DExD/H-box family of ATP-dependent RNA helicases, whose members play multifunctional roles in processes of RNA the metabolism of RNA including transcription, alternative RNA splicing, and RNA degradation []. They bind several mitotic RNAs necessary for terminal differentiation. The presence of the YTH domain allows these proteins to recognise and bind N6-methyadenosine modified fraction of RNAs [, ]. These proteins have a conserved, functional role as critical regulators of the transition from mitosis to meiosis in the germline and ensures the successful progress of the meiotic division. They are indispensable functional binding partners of MEIOC, a meiosis-specific protein thought to regulate male and female meiosis by controlling the stability of various mRNAs []. Human YTHDC2 plays an important role in tumour cells growth [].
