Zinc-finger BED domain-containing protein 3 (Zbed3) is a zinc finger protein that binds to axin and activates the Wnt/beta-catenin signalling. Interaction with axin is important for Zbed3 to inhibit beta-catenin phosphorylation, hence inhibiting beta-catenin degradation []. Zbed3 has been associated with insulin resistance and type 2 diabetes mellitus in humans [, ].
Zinc-finger BED domain-containing protein 3 (Zbed3) is a zinc finger protein that binds to axin and activates the Wnt/beta-catenin signalling. Interaction with axin is important for Zbed3 to inhibit beta-catenin phosphorylation, hence inhibiting beta-catenin degradation []. Zbed3 has been associated with insulin resistance and type 2 diabetes mellitus in humans [, ].This entry includes ZBED2 and ZBED3. The function of ZBED2 is not clear.
