This domain is found in the Zc3h12a protein and NEDD4-binding protein 1. Zc3h12a has been shown to be a ribonuclease that controls the stability of a set of inflammatory genes []. NEDD4-binding protein 1 is a potent suppressor of cytokine production that acts as a regulator of innate immune signaling and inflammation []. This domain belongs to the PIN domain superfamily []and it has also been identified as part of the NYN domain family [].
