ZMYND11 (also known as BS69) was identified as a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions []. ZMYND11 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND domains. The tandem Bromo-PWWP domains of ZMYND11 specifically recognise histone H3.3 trimethylated at lysine 36 (H3.3K36me3), thereby linking ZMYND11 to transcriptional elongation, tumour suppression and pre-mRNA splicing [, ].This PWWP domain is also found in ZMYND8. ZMYND8 recognizes dual histone modification mark H3K4me1-H3K14ac, and can function to counteract gene expression [, ]. Both ZMYND11 and ZMYND8 function in chromatin remodelling, consistent with other PWWP-containing proteins [].
