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Search results 101 to 200 out of 419 for Bace1

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Category: Publication
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Type Details Score
Publication
25384422 | J:218214
First Author: Parr C
Year: 2015
Journal: FASEB J
Title: Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter.
Volume: 29
Issue: 2
Pages: 623-35
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Publication
22223639 | J:182773
First Author: Sadleir KR
Year: 2012
Journal: J Biol Chem
Title: Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease.
Volume: 287
Issue: 10
Pages: 7224-35
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Publication
15364953 | J:337599
First Author: Kitazume S
Year: 2005
Journal: J Biol Chem
Title: In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase.
Volume: 280
Issue: 9
Pages: 8589-95
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Publication
15080893 | J:89370
First Author: Pastorino L
Year: 2004
Journal: Mol Cell Neurosci
Title: BACE (beta-secretase) modulates the processing of APLP2 in vivo.
Volume: 25
Issue: 4
Pages: 642-9
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Publication
20163459 | J:169511
First Author: Sala Frigerio C
Year: 2010
Journal: FEBS J
Title: beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins.
Volume: 277
Issue: 6
Pages: 1503-18
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Publication
15509532 | J:93635
First Author: Willem M
Year: 2004
Journal: Am J Pathol
Title: beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice.
Volume: 165
Issue: 5
Pages: 1621-31
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Publication
10531052 | J:43334
First Author: Vassar R
Year: 1999
Journal: Science
Title: Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Volume: 286
Issue: 5440
Pages: 735-41
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Publication
28004339 | J:325881
First Author: Stertz L
Year: 2018
Journal: Mol Neurobiol
Title: BACE1-Deficient Mice Exhibit Alterations in Immune System Pathways.
Volume: 55
Issue: 1
Pages: 709-717
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Publication
15824102 | J:100272
First Author: Wong HK
Year: 2005
Journal: J Biol Chem
Title: beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.
Volume: 280
Issue: 24
Pages: 23009-17
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Publication
31110178 | J:275557
First Author: Liebsch F
Year: 2019
Journal: Nat Commun
Title: Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.
Volume: 10
Issue: 1
Pages: 2240
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Publication
34500034 | J:312957
 
First Author: Dai L
Year: 2021
Journal: Brain Behav Immun
Title: Elevated β-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease.
Volume: 98
Pages: 337-348
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Publication
16027115 | J:102154
First Author: Rockenstein E
Year: 2005
Journal: J Biol Chem
Title: High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.
Volume: 280
Issue: 38
Pages: 32957-67
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Publication
17409228 | J:119403
First Author: Zhao J
Year: 2007
Journal: J Neurosci
Title: Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.
Volume: 27
Issue: 14
Pages: 3639-49
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Publication
17470798 | J:121585
First Author: Ma H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.
Volume: 104
Issue: 19
Pages: 8167-72
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Publication
22895721 | J:187719
First Author: Chen Y
Year: 2012
Journal: J Neurosci
Title: Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.
Volume: 32
Issue: 33
Pages: 11390-5
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Publication
16420434 | J:105376
First Author: Ohno M
Year: 2006
Journal: Eur J Neurosci
Title: Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
Volume: 23
Issue: 1
Pages: 251-60
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Publication
18650431 | J:142478
First Author: Cole SL
Year: 2008
Journal: J Biol Chem
Title: The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology.
Volume: 283
Issue: 44
Pages: 29621-5
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Publication
20092570 | J:157228
First Author: Zhang XM
Year: 2009
Journal: Eur J Neurosci
Title: Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development.
Volume: 30
Issue: 12
Pages: 2271-83
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Publication
25912880 | J:235920
First Author: Paredes RM
Year: 2015
Journal: Genes Brain Behav
Title: Physiological and behavioral effects of amphetamine in BACE1(-/-) mice.
Volume: 14
Issue: 5
Pages: 411-8
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Publication
20731874 | J:163907
 
First Author: Hitt BD
Year: 2010
Journal: Mol Neurodegener
Title: BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.
Volume: 5
Pages: 31
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Publication
27791018 | J:238803
First Author: Katsouri L
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model.
Volume: 113
Issue: 43
Pages: 12292-12297
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Publication
20505099 | J:160819
First Author: McAllister C
Year: 2010
Journal: J Neurosci
Title: Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment.
Volume: 30
Issue: 21
Pages: 7326-34
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Publication
18986979 | J:146980
First Author: Boissonneault V
Year: 2009
Journal: J Biol Chem
Title: MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1.
Volume: 284
Issue: 4
Pages: 1971-81
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Publication
17157415 | J:135007
First Author: Wang L
Year: 2008
Journal: Neurobiol Aging
Title: Activation of protein kinase C modulates BACE1-mediated beta-secretase activity.
Volume: 29
Issue: 3
Pages: 357-67
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25955795 | J:329858
First Author: Yang G
Year: 2015
Journal: Mol Med Rep
Title: MicroRNA-29c targets β-site amyloid precursor protein-cleaving enzyme 1 and has a neuroprotective role in vitro and in vivo.
Volume: 12
Issue: 2
Pages: 3081-8
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Publication
15606899 | J:95653
First Author: Wickham L
Year: 2005
Journal: J Neurochem
Title: Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.
Volume: 92
Issue: 1
Pages: 93-102
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Publication
15584902 | J:94803
First Author: Yang HC
Year: 2004
Journal: J Neurochem
Title: Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
Volume: 91
Issue: 6
Pages: 1249-59
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26139848 | J:325924
First Author: Dislich B
Year: 2015
Journal: Mol Cell Proteomics
Title: Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.
Volume: 14
Issue: 10
Pages: 2550-63
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Publication
24907271 | J:216006
First Author: He W
Year: 2014
Journal: J Biol Chem
Title: β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.
Volume: 289
Issue: 30
Pages: 20630-7
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Publication
16990514 | J:113726
First Author: Willem M
Year: 2006
Journal: Science
Title: Control of peripheral nerve myelination by the beta-secretase BACE1.
Volume: 314
Issue: 5799
Pages: 664-6
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Publication
15987683 | J:100925
First Author: Dominguez D
Year: 2005
Journal: J Biol Chem
Title: Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.
Volume: 280
Issue: 35
Pages: 30797-806
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23430253 | J:336904
First Author: Stützer I
Year: 2013
Journal: J Biol Chem
Title: Systematic proteomic analysis identifies β-site amyloid precursor protein cleaving enzyme 2 and 1 (BACE2 and BACE1) substrates in pancreatic β-cells.
Volume: 288
Issue: 15
Pages: 10536-47
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30456346 | J:284846
First Author: Voytyuk I
Year: 2018
Journal: Life Sci Alliance
Title: BACE2 distribution in major brain cell types and identification of novel substrates.
Volume: 1
Issue: 1
Pages: e201800026
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22903875 | J:280845
First Author: Cai J
Year: 2012
Journal: EMBO Mol Med
Title: β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment.
Volume: 4
Issue: 9
Pages: 980-91
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21825135 | J:175989
First Author: Sannerud R
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1.
Volume: 108
Issue: 34
Pages: E559-68
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27084579 | J:246510
First Author: Kurkinen KM
Year: 2016
Journal: J Cell Sci
Title: SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
Volume: 129
Issue: 11
Pages: 2224-38
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26663083 | J:259402
First Author: Schnöder L
Year: 2016
Journal: J Biol Chem
Title: Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.
Volume: 291
Issue: 5
Pages: 2067-79
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22912719 | J:189875
First Author: Koike MA
Year: 2012
Journal: PLoS One
Title: APP knockout mice experience acute mortality as the result of ischemia.
Volume: 7
Issue: 8
Pages: e42665
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16354928 | J:123534
First Author: Laird FM
Year: 2005
Journal: J Neurosci
Title: BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.
Volume: 25
Issue: 50
Pages: 11693-709
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23825420 | J:199824
First Author: Bhattacharyya R
Year: 2013
Journal: J Neurosci
Title: Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts.
Volume: 33
Issue: 27
Pages: 11169-83
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32407295 | J:293959
First Author: Meakin PJ
Year: 2020
Journal: J Clin Invest
Title: Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.
Volume: 130
Issue: 8
Pages: 4104-4117
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32913125 | J:348430
First Author: Mori T
Year: 2020
Journal: J Biol Chem
Title: Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice.
Volume: 295
Issue: 48
Pages: 16251-16266
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18660751 | J:138995
First Author: Jonas MC
Year: 2008
Journal: EMBO Rep
Title: PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.
Volume: 9
Issue: 9
Pages: 916-22
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23754390 | J:197977
First Author: Rochin L
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.
Volume: 110
Issue: 26
Pages: 10658-63
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20704561 | J:277904
First Author: Davis W Jr
Year: 2010
Journal: Curr Alzheimer Res
Title: The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation.
Volume: 7
Issue: 7
Pages: 566-77
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26414661 | J:243323
First Author: Maesako M
Year: 2015
Journal: PLoS One
Title: High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.
Volume: 10
Issue: 9
Pages: e0131199
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30120949 | J:270232
 
First Author: Wang M
Year: 2018
Journal: Neurosci Lett
Title: Beta-secretase/BACE1 promotes APP endocytosis and processing in the endosomes and on cell membrane.
Volume: 685
Pages: 63-67
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16267225 | J:102728
First Author: Liang X
Year: 2005
Journal: J Neurosci
Title: Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.
Volume: 25
Issue: 44
Pages: 10180-7
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26322584 | J:226790
First Author: Willem M
Year: 2015
Journal: Nature
Title: η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Volume: 526
Issue: 7573
Pages: 443-7
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18341989 | J:132937
First Author: Wen Y
Year: 2008
Journal: Neuron
Title: Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.
Volume: 57
Issue: 5
Pages: 680-90
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26900752 | J:236654
First Author: Oliverio M
Year: 2016
Journal: Nat Cell Biol
Title: Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function.
Volume: 18
Issue: 3
Pages: 328-36
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22836275 | J:186537
First Author: Walker KR
Year: 2012
Journal: J Neurosci
Title: Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
Volume: 32
Issue: 30
Pages: 10423-37
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24005676 | J:207246
First Author: Deng M
Year: 2013
Journal: J Biol Chem
Title: Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.
Volume: 288
Issue: 42
Pages: 30236-45
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22988240 | J:192472
First Author: Hitt B
Year: 2012
Journal: J Biol Chem
Title: β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.
Volume: 287
Issue: 46
Pages: 38408-25
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23335052 | J:197749
First Author: Hu X
Year: 2013
Journal: FASEB J
Title: Reversing hypomyelination in BACE1-null mice with Akt-DD overexpression.
Volume: 27
Issue: 5
Pages: 1868-73
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20092558 | J:158363
First Author: Devi L
Year: 2010
Journal: Eur J Neurosci
Title: Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.
Volume: 31
Issue: 1
Pages: 110-8
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29311632 | J:260174
First Author: Meakin PJ
Year: 2018
Journal: Sci Rep
Title: Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice.
Volume: 8
Issue: 1
Pages: 55
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15745965 | J:98609
First Author: Lazarov O
Year: 2005
Journal: J Neurosci
Title: Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
Volume: 25
Issue: 9
Pages: 2386-95
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18385378 | J:133643
First Author: Savonenko AV
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice.
Volume: 105
Issue: 14
Pages: 5585-90
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29979789 | J:263821
First Author: Causevic M
Year: 2018
Journal: PLoS One
Title: BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.
Volume: 13
Issue: 7
Pages: e0200344
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21190943 | J:170564
First Author: Kim DY
Year: 2011
Journal: J Biol Chem
Title: Reduced sodium channel Na(v)1.1 levels in BACE1-null mice.
Volume: 286
Issue: 10
Pages: 8106-16
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32921309 | J:324398
First Author: Johnson ECB
Year: 2020
Journal: Mol Neurodegener
Title: Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.
Volume: 15
Issue: 1
Pages: 53
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34302009 | J:359845
First Author: Nash A
Year: 2021
Journal: Sci Rep
Title: BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory.
Volume: 11
Issue: 1
Pages: 15084
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22049418 | J:177847
First Author: Giusti-Rodríguez P
Year: 2011
Journal: J Neurosci
Title: Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1).
Volume: 31
Issue: 44
Pages: 15751-6
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11224535 | J:67736
First Author: Luo Y
Year: 2001
Journal: Nat Neurosci
Title: Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
Volume: 4
Issue: 3
Pages: 231-2
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11406613 | J:77414
First Author: Roberds SL
Year: 2001
Journal: Hum Mol Genet
Title: BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics.
Volume: 10
Issue: 12
Pages: 1317-24
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19287391 | J:149374
First Author: Loane DJ
Year: 2009
Journal: Nat Med
Title: Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.
Volume: 15
Issue: 4
Pages: 377-9
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21933711 | J:179837
First Author: Devi L
Year: 2012
Journal: Neurobiol Dis
Title: Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice.
Volume: 45
Issue: 1
Pages: 417-24
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18945886 | J:144634
First Author: Varvel NH
Year: 2008
Journal: J Neurosci
Title: Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.
Volume: 28
Issue: 43
Pages: 10786-93
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22249458 | J:318112
First Author: Park MH
Year: 2012
Journal: J Neuropathol Exp Neurol
Title: Mutant presenilin 2 increases β-secretase activity through reactive oxygen species-dependent activation of extracellular signal-regulated kinase.
Volume: 71
Issue: 2
Pages: 130-9
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26661166 | J:318355
First Author: Devraj K
Year: 2016
Journal: J Cereb Blood Flow Metab
Title: BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.
Volume: 36
Issue: 7
Pages: 1281-94
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27517085 | J:237784
 
First Author: Cheng N
Year: 2016
Journal: eNeuro
Title: APP Overexpression Causes Aβ-Independent Neuronal Death through Intrinsic Apoptosis Pathway.
Volume: 3
Issue: 4
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38311982 | J:345924
First Author: Hong J
Year: 2024
Journal: Glia
Title: PMP2 regulates myelin thickening and ATP production during remyelination.
Volume: 72
Issue: 5
Pages: 885-898
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24806669 | J:211050
First Author: Kallop DY
Year: 2014
Journal: J Neurosci
Title: A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.
Volume: 34
Issue: 19
Pages: 6425-37
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36716914 | J:347459
 
First Author: Murray HC
Year: 2023
Journal: Neuroscience
Title: Progressive Spread of Beta-amyloid Pathology in an Olfactory-driven Amyloid Precursor Protein Mouse Model.
Volume: 516
Pages: 113-124
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23931995 | J:266459
First Author: Das U
Year: 2013
Journal: Neuron
Title: Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.
Volume: 79
Issue: 3
Pages: 447-60
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26755586 | J:229925
First Author: Lee YI
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions.
Volume: 113
Issue: 4
Pages: E479-87
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28696204 | J:257152
   
First Author: Puzzo D
Year: 2017
Journal: Elife
Title: LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent.
Volume: 6
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20097169 | J:158017
First Author: Jin S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Evidence for dimeric BACE-mediated APP processing.
Volume: 393
Issue: 1
Pages: 21-7
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27576688 | J:237285
First Author: Qin X
Year: 2016
Journal: J Biol Chem
Title: Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain.
Volume: 291
Issue: 42
Pages: 22276-22287
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21542009 | J:184350
First Author: Cui S
Year: 2011
Journal: J Bone Miner Res
Title: APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner.
Volume: 26
Issue: 5
Pages: 1084-98
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19683527 | J:152969
First Author: Philipson O
Year: 2009
Journal: FEBS Lett
Title: Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
Volume: 583
Issue: 18
Pages: 3021-6
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