|  Help  |  About  |  Contact Us

Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 186 out of 186 for Dvl2

Category restricted to Publication (x)

<< First    < Previous  |  Next >    Last >>
0.034s

Categories

Category: Publication
« show all
Type Details Score
Publication
18701545 | J:139139
First Author: García-García MJ
Year: 2008
Journal: Development
Title: Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.
Volume: 135
Issue: 18
Pages: 3053-62
•
•
•
•
•
Publication
34032267 | J:308827
 
First Author: Kaiser K
Year: 2021
Journal: Development
Title: MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.
Volume: 148
Issue: 10
•
•
•
•
•
Publication
19300477 | J:147041
First Author: Matsuyama M
Year: 2009
Journal: PLoS Genet
Title: Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium.
Volume: 5
Issue: 3
Pages: e1000427
•
•
•
•
•
Publication
24852369 | J:211696
First Author: Goggolidou P
Year: 2014
Journal: Hum Mol Genet
Title: Atmin mediates kidney morphogenesis by modulating Wnt signaling.
Volume: 23
Issue: 20
Pages: 5303-16
•
•
•
•
•
Publication
35514236 | J:325944
 
First Author: Zhao T
Year: 2022
Journal: Dis Model Mech
Title: The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice.
Volume: 15
Issue: 6
•
•
•
•
•
Publication
25073924 | J:269440
 
First Author: Morgan-Smith M
Year: 2014
Journal: Elife
Title: GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.
Volume: 3
Pages: e02663
•
•
•
•
•
Publication
32511952 | J:293794
First Author: Durbin MD
Year: 2020
Journal: Dev Biol
Title: SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects.
Volume: 464
Issue: 2
Pages: 124-136
•
•
•
•
•
Publication
24284205 | J:206311
First Author: Zhao T
Year: 2014
Journal: Development
Title: β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation.
Volume: 141
Issue: 1
Pages: 148-57
•
•
•
•
•
Publication
21177343 | J:167714
First Author: Li D
Year: 2011
Journal: Development
Title: Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Volume: 138
Issue: 2
Pages: 303-15
•
•
•
•
•
Publication
23533177 | J:195272
First Author: Sipe CW
Year: 2013
Journal: Development
Title: Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization.
Volume: 140
Issue: 8
Pages: 1785-95
•
•
•
•
•
Publication
27582005 | J:235788
First Author: Nagy II
Year: 2016
Journal: BMC Dev Biol
Title: Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis.
Volume: 16
Issue: 1
Pages: 30
•
•
•
•
•
Publication
39366759 | J:355261
 
First Author: Rehmani T
Year: 2024
Journal: Life Sci Alliance
Title: SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP.
Volume: 7
Issue: 12
•
•
•
•
•
Publication
30254141 | J:272616
 
First Author: Iwai-Takekoshi L
Year: 2018
Journal: Development
Title: Activation of Wnt signaling reduces ipsilaterally projecting retinal ganglion cells in pigmented retina.
Volume: 145
Issue: 21
•
•
•
•
•
Publication
24302887 | J:205269
First Author: Cui C
Year: 2013
Journal: PLoS Biol
Title: Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.
Volume: 11
Issue: 11
Pages: e1001720
•
•
•
•
•
Publication
32907846 | J:297063
 
First Author: Najarro EH
Year: 2020
Journal: Development
Title: Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.
Volume: 147
Issue: 19
•
•
•
•
•
Publication
23190887 | J:196515
First Author: Fu J
Year: 2013
Journal: J Invest Dermatol
Title: Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis.
Volume: 133
Issue: 4
Pages: 890-8
•
•
•
•
•
Publication
34157307 | J:308817
First Author: Fu Y
Year: 2021
Journal: Mol Cell
Title: OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.
Volume: 81
Issue: 15
Pages: 3187-3204.e7
•
•
•
•
•
Publication
23177622 | J:269131
First Author: Cortijo C
Year: 2012
Journal: Cell Rep
Title: Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis.
Volume: 2
Issue: 6
Pages: 1593-606
•
•
•
•
•
Publication
30022023 | J:266389
First Author: Yin W
Year: 2018
Journal: Nat Commun
Title: The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.
Volume: 9
Issue: 1
Pages: 2815
•
•
•
•
•
Publication
15142957 | J:174497
First Author: Funatsu N
Year: 2004
Journal: Cereb Cortex
Title: Gene expression analysis of the late embryonic mouse cerebral cortex using DNA microarray: identification of several region- and layer-specific genes.
Volume: 14
Issue: 9
Pages: 1031-44
•
•
•
•
•
Publication
18351662 | J:132979
First Author: Potok MA
Year: 2008
Journal: Dev Dyn
Title: WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth.
Volume: 237
Issue: 4
Pages: 1006-20
•
•
•
•
•
Publication
32253237 | J:293624
 
First Author: Lee S
Year: 2020
Journal: Development
Title: Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk.
Volume: 147
Issue: 21
•
•
•
•
•
Publication
33141892 | J:298302
First Author: Ru J
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.
Volume: 61
Issue: 13
Pages: 6
•
•
•
•
•
Publication
15306695 | J:91835
First Author: Kaput J
Year: 2004
Journal: Physiol Genomics
Title: Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
Volume: 18
Issue: 3
Pages: 316-24
•
•
•
•
•
Publication
18351675 | J:122362
First Author: Harwood BN
Year: 2008
Journal: Dev Dyn
Title: Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.
Volume: 237
Issue: 4
Pages: 1099-111
•
•
•
•
•
Publication
19515997 | J:154534
First Author: Martinez G
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
Volume: 50
Issue: 10
Pages: 4794-806
•
•
•
•
•
Publication
- | J:29126
     
First Author: The Jackson Laboratory DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX Interspecific Backcross BSS and BSB Public Mapping Data
•
•
•
•
•
Publication
- | J:46439
     
First Author: Freeman TC
Year: 1998
Journal: MGI Direct Data Submission
Title: Expression Mapping of Mouse Genes
•
•
•
•
•
Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
•
•
•
•
•
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
21691068 | -
First Author: Zhang Y
Year: 2011
Journal: Cell Physiol Biochem
Title: GABARAPL1 negatively regulates Wnt/β-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.
Volume: 27
Issue: 5
Pages: 503-12
•
•
•
•
•
Publication
34139860 | -
First Author: Zhao D
Year: 2021
Journal: Circulation
Title: Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.
Volume: 144
Issue: 9
Pages: 694-711
•
•
•
•
•
Publication
28334810 | J:242589
First Author: Seo HS
Year: 2017
Journal: Hum Mol Genet
Title: Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis.
Volume: 26
Issue: 11
Pages: 2053-2061
•
•
•
•
•
Publication
24711502 | J:215806
First Author: Bentzinger CF
Year: 2014
Journal: J Cell Biol
Title: Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength.
Volume: 205
Issue: 1
Pages: 97-111
•
•
•
•
•
Publication
27477274 | J:238983
First Author: Jin X
Year: 2016
Journal: Cell Rep
Title: The ID1-CULLIN3 Axis Regulates Intracellular SHH and WNT Signaling in Glioblastoma Stem Cells.
Volume: 16
Issue: 6
Pages: 1629-1641
•
•
•
•
•
Publication
28963394 | J:249243
First Author: Morgenstern Y
Year: 2017
Journal: EMBO J
Title: Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.
Volume: 36
Issue: 20
Pages: 3046-3061
•
•
•
•
•
Publication
37260921 | J:336154
   
First Author: Rim EY
Year: 2023
Journal: MicroPubl Biol
Title: APEX2-Mediated Proximity Labeling of Wnt Receptor Interactors Upon Pathway Activation.
Volume: 2023
•
•
•
•
•
Publication
9407023 | J:45118
First Author: Cadigan KM
Year: 1997
Journal: Genes Dev
Title: Wnt signaling: a common theme in animal development.
Volume: 11
Issue: 24
Pages: 3286-305
•
•
•
•
•
Publication
10318824 | J:54993
First Author: Sakanaka C
Year: 1999
Journal: J Biol Chem
Title: Functional domains of axin. Importance of the C terminus as an oligomerization domain.
Volume: 274
Issue: 20
Pages: 14090-3
•
•
•
•
•
Publication
10330181 | -
First Author: Kishida S
Year: 1999
Journal: Mol Cell Biol
Title: DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
Volume: 19
Issue: 6
Pages: 4414-22
•
•
•
•
•
Publication
11041490 | -
First Author: Fukui A
Year: 2000
Journal: Dev Growth Differ
Title: Effects of rat Axin domains on axis formation in Xenopus embryos.
Volume: 42
Issue: 5
Pages: 489-98
•
•
•
•
•
Publication
11027605 | -
First Author: Julius MA
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Domains of axin and disheveled required for interaction and function in wnt signaling.
Volume: 276
Issue: 3
Pages: 1162-9
•
•
•
•
•
Publication
12384700 | -
First Author: Capelluto DG
Year: 2002
Journal: Nature
Title: The DIX domain targets dishevelled to actin stress fibres and vesicular membranes.
Volume: 419
Issue: 6908
Pages: 726-9
•
•
•
•
•
Publication
19001364 | J:219089
First Author: Andersson T
Year: 2009
Journal: J Biol Chem
Title: CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells.
Volume: 284
Issue: 6
Pages: 3672-81
•
•
•
•
•
Publication
21317929 | J:173694
First Author: Li Y
Year: 2011
Journal: Oncogene
Title: HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression.
Volume: 30
Issue: 23
Pages: 2633-43
•
•
•
•
•
Publication
10769039 | J:61768
First Author: Charpentier E
Year: 2000
Journal: J Cell Biol
Title: Plakoglobin suppresses epithelial proliferation and hair growth in vivo.
Volume: 149
Issue: 2
Pages: 503-20
•
•
•
•
•
Publication
22128168 | J:179664
First Author: Yamagata K
Year: 2012
Journal: J Biol Chem
Title: Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression.
Volume: 287
Issue: 2
Pages: 1588-99
•
•
•
•
•
Publication
35144597 | J:322488
First Author: Kim Y
Year: 2022
Journal: BMC Biol
Title: DIX domain containing 1 (DIXDC1) modulates VEGFR2 level in vasculatures to regulate embryonic and postnatal retina angiogenesis.
Volume: 20
Issue: 1
Pages: 41
•
•
•
•
•
Publication
20837657 | J:164680
First Author: Singh J
Year: 2010
Journal: Genes Dev
Title: Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation.
Volume: 24
Issue: 19
Pages: 2157-68
•
•
•
•
•
Publication
16446366 | J:111564
First Author: Zhang L
Year: 2006
Journal: J Biol Chem
Title: Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.
Volume: 281
Issue: 13
Pages: 8607-12
•
•
•
•
•
Publication
21697359 | J:173523
First Author: Wilkinson MB
Year: 2011
Journal: J Neurosci
Title: A novel role of the WNT-dishevelled-GSK3β signaling cascade in the mouse nucleus accumbens in a social defeat model of depression.
Volume: 31
Issue: 25
Pages: 9084-92
•
•
•
•
•
Publication
22328498 | J:197303
First Author: Endo M
Year: 2012
Journal: J Cell Sci
Title: Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex.
Volume: 125
Issue: Pt 8
Pages: 2017-29
•
•
•
•
•
Publication
29659741 | J:298070
First Author: Lian G
Year: 2019
Journal: Cereb Cortex
Title: Formin 2 Regulates Lysosomal Degradation of Wnt-Associated β-Catenin in Neural Progenitors.
Volume: 29
Issue: 5
Pages: 1938-1952
•
•
•
•
•
Publication
31867777 | J:300618
First Author: Novellasdemunt L
Year: 2020
Journal: EMBO J
Title: NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.
Volume: 39
Issue: 3
Pages: e102771
•
•
•
•
•
Publication
12948650 | -
First Author: Copp AJ
Year: 2003
Journal: Trends Neurosci
Title: Dishevelled: linking convergent extension with neural tube closure.
Volume: 26
Issue: 9
Pages: 453-5
•
•
•
•
•
Publication
15857680 | J:97956
First Author: Shiomi K
Year: 2005
Journal: Brain Res Mol Brain Res
Title: Identification and differential expression of multiple isoforms of mouse Coiled-coil-DIX1 (Ccd1), a positive regulator of Wnt signaling.
Volume: 135
Issue: 1-2
Pages: 169-80
•
•
•
•
•
Publication
34733849 | J:312854
 
First Author: Zhong G
Year: 2021
Journal: Front Cell Dev Biol
Title: WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity.
Volume: 9
Pages: 739944
•
•
•
•
•
Publication
15262978 | -
First Author: Wong CK
Year: 2004
Journal: J Biol Chem
Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
Volume: 279
Issue: 38
Pages: 39366-73
•
•
•
•
•
Publication
12072470 | -
First Author: Penton A
Year: 2002
Journal: Genetics
Title: A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin.
Volume: 161
Issue: 2
Pages: 747-62
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom