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Search results 101 to 200 out of 204 for Hcn4

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Type Details Score
Publication
25487574 | J:224301
First Author: Harris JP
Year: 2015
Journal: Mol Cell Biol
Title: MyoR modulates cardiac conduction by repressing Gata4.
Volume: 35
Issue: 4
Pages: 649-61
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Publication
30936836 | J:314288
 
First Author: Samal E
Year: 2019
Journal: Front Physiol
Title: Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System.
Volume: 10
Pages: 235
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Publication
36255053 | J:331268
   
First Author: Ding Y
Year: 2022
Journal: Elife
Title: A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene.
Volume: 11
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Publication
32675240 | J:295904
First Author: Mohan RA
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: T-box transcription factor 3 governs a transcriptional program for the function of the mouse atrioventricular conduction system.
Volume: 117
Issue: 31
Pages: 18617-18626
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Publication
14633990 | J:86837
First Author: Kuwahara K
Year: 2003
Journal: EMBO J
Title: NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function.
Volume: 22
Issue: 23
Pages: 6310-21
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Publication
17482496 | J:122471
First Author: Hattori K
Year: 2007
Journal: Mol Genet Metab
Title: Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.
Volume: 91
Issue: 3
Pages: 285-93
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Publication
27396331 | J:238678
First Author: Ishida H
Year: 2016
Journal: Cell Rep
Title: GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway.
Volume: 16
Issue: 4
Pages: 1026-1038
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Publication
32672536 | J:293906
   
First Author: van Weerd JH
Year: 2020
Journal: Elife
Title: Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction.
Volume: 9
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Publication
30270038 | J:267411
First Author: Jiang Z
Year: 2018
Journal: Cell
Title: Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.
Volume: 175
Issue: 3
Pages: 652-664.e12
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Publication
23255421 | J:212863
First Author: Mommersteeg MT
Year: 2013
Journal: Circ Res
Title: Slit-roundabout signaling regulates the development of the cardiac systemic venous return and pericardium.
Volume: 112
Issue: 3
Pages: 465-75
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Publication
30735130 | J:274700
   
First Author: Poltavski DM
Year: 2019
Journal: Elife
Title: Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin.
Volume: 8
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Publication
28287088 | J:245018
 
First Author: Fujii M
Year: 2017
Journal: Nat Commun
Title: Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle.
Volume: 8
Pages: 14664
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Publication
31591643 | J:302410
First Author: Wang Y
Year: 2020
Journal: Cardiovasc Res
Title: Control of sinus venous valve and sinoatrial node development by endocardial NOTCH1.
Volume: 116
Issue: 8
Pages: 1473-1486
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Publication
29107716 | J:276621
 
First Author: Semmler J
Year: 2018
Journal: Pharmacol Res
Title: Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.
Volume: 128
Pages: 200-210
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Publication
25126785 | J:214586
First Author: Duan X
Year: 2014
Journal: Cell
Title: Type II cadherins guide assembly of a direction-selective retinal circuit.
Volume: 158
Issue: 4
Pages: 793-807
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Publication
36736300 | J:333140
First Author: Dominguez MH
Year: 2023
Journal: Cell
Title: Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart.
Volume: 186
Issue: 3
Pages: 479-496.e23
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Publication
27180262 | J:250657
 
First Author: Greulich F
Year: 2016
Journal: J Mol Cell Cardiol
Title: Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.
Volume: 97
Pages: 140-9
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Publication
21266775 | J:171828
First Author: Aanhaanen WT
Year: 2011
Journal: J Clin Invest
Title: Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice.
Volume: 121
Issue: 2
Pages: 534-44
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Publication
29611808 | J:263281
   
First Author: Ray TA
Year: 2018
Journal: Elife
Title: Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact.
Volume: 7
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Publication
28195173 | J:244630
 
First Author: Bardot E
Year: 2017
Journal: Nat Commun
Title: Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.
Volume: 8
Pages: 14428
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Publication
28111199 | J:253913
First Author: Guimarães-Camboa N
Year: 2017
Journal: Cell Stem Cell
Title: Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.
Volume: 20
Issue: 3
Pages: 345-359.e5
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Publication
23172916 | J:189955
First Author: Star EN
Year: 2012
Journal: Development
Title: Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6.
Volume: 139
Issue: 24
Pages: 4644-55
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Publication
18467625 | J:149014
First Author: Bakker ML
Year: 2008
Journal: Circ Res
Title: Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system.
Volume: 102
Issue: 11
Pages: 1340-9
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Publication
27725084 | J:238633
   
First Author: Tyser RC
Year: 2016
Journal: Elife
Title: Calcium handling precedes cardiac differentiation to initiate the first heartbeat.
Volume: 5
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Publication
35951416 | J:330742
 
First Author: Goodyer WR
Year: 2022
Journal: J Clin Invest
Title: In vivo visualization and molecular targeting of the cardiac conduction system.
Volume: 132
Issue: 20
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Publication
26287463 | J:225578
First Author: Krishnaswamy A
Year: 2015
Journal: Nature
Title: Sidekick 2 directs formation of a retinal circuit that detects differential motion.
Volume: 524
Issue: 7566
Pages: 466-470
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Publication
20185795 | J:171035
First Author: Norden J
Year: 2010
Journal: Circ Res
Title: Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.
Volume: 106
Issue: 7
Pages: 1212-20
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Publication
22158708 | J:192707
First Author: He A
Year: 2012
Journal: Circ Res
Title: Polycomb repressive complex 2 regulates normal development of the mouse heart.
Volume: 110
Issue: 3
Pages: 406-15
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Publication
31286141 | J:306226
First Author: Firulli BA
Year: 2020
Journal: Cardiovasc Res
Title: HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.
Volume: 116
Issue: 3
Pages: 605-618
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Publication
17473172 | J:121230
First Author: Hoogaars WM
Year: 2007
Journal: Genes Dev
Title: Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.
Volume: 21
Issue: 9
Pages: 1098-112
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Publication
28302382 | J:251389
 
First Author: Zakariyah AF
Year: 2017
Journal: J Mol Cell Cardiol
Title: Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.
Volume: 105
Pages: 89-98
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Publication
34062094 | J:339247
First Author: Zhang C
Year: 2021
Journal: Open Biol
Title: Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation.
Volume: 11
Issue: 6
Pages: 210020
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Publication
33443158 | J:299975
 
First Author: Gharibeh L
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: GATA6 is a regulator of sinus node development and heart rhythm.
Volume: 118
Issue: 1
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Publication
31968244 | J:287680
First Author: Yamamoto H
Year: 2020
Journal: Cell Rep
Title: Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development.
Volume: 30
Issue: 3
Pages: 658-671.e5
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Publication
30787001 | J:273025
 
First Author: Moreau JLM
Year: 2019
Journal: Development
Title: Gene-environment interaction impacts on heart development and embryo survival.
Volume: 146
Issue: 4
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Publication
39366945 | J:355142
First Author: Gómez-Del Arco P
Year: 2024
Journal: Nat Commun
Title: The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development.
Volume: 15
Issue: 1
Pages: 8602
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Publication
22130515 | J:181526
First Author: Singh R
Year: 2012
Journal: Cell Mol Life Sci
Title: Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation.
Volume: 69
Issue: 8
Pages: 1377-89
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Publication
28199486 | J:240687
First Author: Park KU
Year: 2017
Journal: Invest Ophthalmol Vis Sci
Title: Gsg1, Trnp1, and Tmem215 Mark Subpopulations of Bipolar Interneurons in the Mouse Retina.
Volume: 58
Issue: 2
Pages: 1137-1150
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Publication
16707424 | J:109061
First Author: Fenske TS
Year: 2006
Journal: Cancer Res
Title: Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.
Volume: 66
Issue: 10
Pages: 5029-38
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Publication
25053429 | J:214093
First Author: Cambier L
Year: 2014
Journal: Development
Title: Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.
Volume: 141
Issue: 15
Pages: 2959-71
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Publication
21757651 | J:188836
First Author: Norden J
Year: 2011
Journal: Circ Res
Title: Wnt/β-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation.
Volume: 109
Issue: 6
Pages: e42-50
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Publication
29891551 | J:267108
First Author: Cho E
Year: 2018
Journal: J Biol Chem
Title: Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.
Volume: 293
Issue: 30
Pages: 11659-11673
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Publication
30936179 | J:274879
 
First Author: van Eif VWW
Year: 2019
Journal: Development
Title: Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program.
Volume: 146
Issue: 8
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Publication
- | J:322048
     
First Author: The Centre for Phenogenomics
Year: 2022
Journal: MGI Direct Data Submission
Title: Direct Data Submission for The Centre for Phenogenomics Alleles.
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Publication
16985003 | J:119550
First Author: Harrell MD
Year: 2007
Journal: Physiol Genomics
Title: Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Volume: 28
Issue: 3
Pages: 273-83
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
19477969 | J:167965
First Author: Kuratomi S
Year: 2009
Journal: Cardiovasc Res
Title: The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2.
Volume: 83
Issue: 4
Pages: 682-7
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Publication
28821541 | J:267993
First Author: D'Souza A
Year: 2017
Journal: Circ Res
Title: Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.
Volume: 121
Issue: 9
Pages: 1058-1068
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Publication
32647060 | J:292477
First Author: Peters CH
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Isoform-specific regulation of HCN4 channels by a family of endoplasmic reticulum proteins.
Volume: 117
Issue: 30
Pages: 18079-18090
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11675786 | -
First Author: Stevens DR
Year: 2001
Journal: Nature
Title: Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.
Volume: 413
Issue: 6856
Pages: 631-5
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29352247 | J:264492
First Author: Sutcliffe MD
Year: 2018
Journal: Sci Rep
Title: High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.
Volume: 8
Issue: 1
Pages: 1258
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31116981 | J:288490
First Author: Fernandez-Perez A
Year: 2019
Journal: Cell Rep
Title: Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming.
Volume: 27
Issue: 8
Pages: 2354-2369.e7
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25145359 | J:315376
First Author: Wu M
Year: 2014
Journal: Cell Res
Title: Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node.
Volume: 24
Issue: 10
Pages: 1201-13
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22006928 | J:202583
First Author: Lolicato M
Year: 2011
Journal: J Biol Chem
Title: Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
Volume: 286
Issue: 52
Pages: 44811-20
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24281837 | J:207828
First Author: Wu M
Year: 2014
Journal: Genesis
Title: Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice.
Volume: 52
Issue: 2
Pages: 134-40
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Publication
25344074 | J:244244
First Author: Nam YJ
Year: 2014
Journal: Development
Title: Induction of diverse cardiac cell types by reprogramming fibroblasts with cardiac transcription factors.
Volume: 141
Issue: 22
Pages: 4267-78
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17261653 | J:132333
First Author: Knaus A
Year: 2007
Journal: Circulation
Title: Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine.
Volume: 115
Issue: 7
Pages: 872-80
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35002623 | J:321658
 
First Author: Deng PY
Year: 2021
Journal: Front Mol Neurosci
Title: Hyperexcitability of Sensory Neurons in Fragile X Mouse Model.
Volume: 14
Pages: 796053
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21674500 | J:179853
First Author: Shi Z
Year: 2012
Journal: J Comp Neurol
Title: Requirement for the paired-like homeodomain transcription factor VSX1 in type 3a mouse retinal bipolar cell terminal differentiation.
Volume: 520
Issue: 1
Pages: 117-29
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24278453 | J:209774
First Author: Groenke S
Year: 2013
Journal: PLoS One
Title: Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.
Volume: 8
Issue: 11
Pages: e81633
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Publication
30502054 | J:302999
 
First Author: Urbanska M
Year: 2019
Journal: EBioMedicine
Title: GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation.
Volume: 39
Pages: 377-387
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30914453 | J:290282
 
First Author: Edling CE
Year: 2019
Journal: Biosci Rep
Title: Ageing in Pgc-1β-/- mice modelling mitochondrial dysfunction induces differential expression of a range of genes regulating ventricular electrophysiology.
Volume: 39
Issue: 4
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Publication
36982627 | J:345096
 
First Author: Loi M
Year: 2023
Journal: Int J Mol Sci
Title: Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder.
Volume: 24
Issue: 6
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32050579 | J:297877
 
First Author: Hoelscher SC
Year: 2020
Journal: Int J Mol Sci
Title: miR-128a Acts as a Regulator in Cardiac Development by Modulating Differentiation of Cardiac Progenitor Cell Populations.
Volume: 21
Issue: 3
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16079136 | J:200307
First Author: Zong X
Year: 2005
Journal: J Biol Chem
Title: A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase.
Volume: 280
Issue: 40
Pages: 34224-32
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Publication
19276108 | J:147575
First Author: Wu Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Volume: 106
Issue: 14
Pages: 5972-7
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Publication
16043489 | J:320090
First Author: Stieber J
Year: 2005
Journal: J Biol Chem
Title: Functional expression of the human HCN3 channel.
Volume: 280
Issue: 41
Pages: 34635-43
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25623957 | J:249182
First Author: Vedantham V
Year: 2015
Journal: Circ Res
Title: RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells.
Volume: 116
Issue: 5
Pages: 797-803
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Publication
27670841 | J:303007
First Author: Oginsky MF
Year: 2017
Journal: J Cell Physiol
Title: Hyperexcitability of Mesencephalic Trigeminal Neurons and Reorganization of Ion Channel Expression in a Rett Syndrome Model.
Volume: 232
Issue: 5
Pages: 1151-1164
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First Author: Feigenspan A
Year: 2004
Journal: J Neurosci
Title: Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina.
Volume: 24
Issue: 13
Pages: 3325-34
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Publication
22948144 | J:192134
First Author: Ramakrishnan NA
Year: 2012
Journal: J Biol Chem
Title: HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
Volume: 287
Issue: 45
Pages: 37628-46
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Publication
25172903 | J:218702
First Author: Lai MH
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo.
Volume: 307
Issue: 9
Pages: H1327-38
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Publication
22307665 | J:186580
First Author: Harris BS
Year: 2012
Journal: Am J Physiol Heart Circ Physiol
Title: Remodeling of the peripheral cardiac conduction system in response to pressure overload.
Volume: 302
Issue: 8
Pages: H1712-25
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Publication
36649430 | J:333562
First Author: Miyamoto M
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Cardiac progenitors instruct second heart field fate through Wnts.
Volume: 120
Issue: 4
Pages: e2217687120
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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