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Search results 101 to 200 out of 367 for Irs1

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Category: Publication
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Type Details Score
Publication
12933351 | J:107745
First Author: Minami K
Year: 2003
Journal: Am J Physiol Endocrinol Metab
Title: ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling.
Volume: 285
Issue: 6
Pages: E1289-96
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Publication
7488102 | J:30271
First Author: Furusaka A
Year: 1995
Journal: Biochem Biophys Res Commun
Title: Ornithine decarboxylase induction during liver regeneration in IRS-1-deficient mice.
Volume: 216
Issue: 1
Pages: 284-90
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Publication
10615953 | J:107128
First Author: Terauchi Y
Year: 2000
Journal: Diabetes
Title: Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.
Volume: 49
Issue: 1
Pages: 82-6
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Publication
9062343 | J:38899
First Author: Terauchi Y
Year: 1997
Journal: J Clin Invest
Title: Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.
Volume: 99
Issue: 5
Pages: 861-6
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Publication
21454638 | J:173503
First Author: Nakatsu Y
Year: 2011
Journal: J Biol Chem
Title: Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.
Volume: 286
Issue: 23
Pages: 20812-22
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Publication
19546233 | J:152621
First Author: Nakao R
Year: 2009
Journal: Mol Cell Biol
Title: Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.
Volume: 29
Issue: 17
Pages: 4798-811
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Publication
20144759 | J:161178
First Author: Nakamura T
Year: 2010
Journal: Cell
Title: Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.
Volume: 140
Issue: 3
Pages: 338-48
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Publication
27439864 | J:235137
First Author: Metz HE
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma.
Volume: 113
Issue: 31
Pages: 8795-800
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Publication
27623927 | J:316681
First Author: Guo Y
Year: 2016
Journal: FASEB J
Title: Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Iα2 expression via miR-342.
Volume: 30
Issue: 12
Pages: 4214-4226
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Publication
21986524 | J:271696
First Author: Ahn J
Year: 2011
Journal: Biochem Biophys Res Commun
Title: High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis.
Volume: 414
Issue: 4
Pages: 664-9
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Publication
12524443 | J:82581
First Author: Borge PD Jr
Year: 2003
Journal: J Biol Chem
Title: Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells.
Volume: 278
Issue: 13
Pages: 11359-68
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Publication
15849359 | J:100275
First Author: Kim JA
Year: 2005
Journal: J Biol Chem
Title: Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance.
Volume: 280
Issue: 24
Pages: 23173-83
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Publication
25586176 | J:265598
First Author: Ando Y
Year: 2015
Journal: J Biol Chem
Title: Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes.
Volume: 290
Issue: 9
Pages: 5881-92
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Publication
8448209 | J:4645
First Author: Keller SR
Year: 1993
Journal: Biochim Biophys Acta
Title: The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning.
Volume: 1172
Issue: 3
Pages: 323-6
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Publication
7675087 | J:38317
First Author: Sun XJ
Year: 1995
Journal: Nature
Title: Role of IRS-2 in insulin and cytokine signalling.
Volume: 377
Issue: 6545
Pages: 173-7
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Publication
9892694 | J:52283
First Author: Dougherty KM
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival.
Volume: 96
Issue: 2
Pages: 686-91
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Publication
12665856 | J:84912
First Author: Ueno H
Year: 2003
Journal: Nat Immunol
Title: A stromal cell-derived membrane protein that supports hematopoietic stem cells.
Volume: 4
Issue: 5
Pages: 457-63
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Publication
23965929 | J:214362
 
First Author: Yi JS
Year: 2013
Journal: Nat Commun
Title: MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.
Volume: 4
Pages: 2354
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Publication
14673165 | J:87598
First Author: Chen D
Year: 2004
Journal: Mol Cell Biol
Title: p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.
Volume: 24
Issue: 1
Pages: 320-9
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Publication
29259227 | J:315967
First Author: Jeong H
Year: 2017
Journal: Sci Rep
Title: Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways.
Volume: 7
Issue: 1
Pages: 17777
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Publication
12765966 | J:83538
First Author: Kulkarni RN
Year: 2003
Journal: Diabetes
Title: Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.
Volume: 52
Issue: 6
Pages: 1528-34
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Publication
9038347 | J:38502
First Author: Brüning JC
Year: 1997
Journal: Cell
Title: Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.
Volume: 88
Issue: 4
Pages: 561-72
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Publication
11517161 | J:115421
First Author: Richards RG
Year: 2001
Journal: Endocrinology
Title: E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway.
Volume: 142
Issue: 9
Pages: 3842-9
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Publication
15689562 | J:98107
First Author: Yi X
Year: 2005
Journal: J Neurosci
Title: Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.
Volume: 25
Issue: 5
Pages: 1240-8
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Publication
15161756 | J:90381
First Author: Kulkarni RN
Year: 2004
Journal: Diabetes
Title: Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.
Volume: 53
Issue: 6
Pages: 1517-25
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Publication
15467829 | J:93415
First Author: Lin X
Year: 2004
Journal: J Clin Invest
Title: Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.
Volume: 114
Issue: 7
Pages: 908-16
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Publication
12746333 | J:83689
First Author: Lee AV
Year: 2003
Journal: Endocrinology
Title: Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.
Volume: 144
Issue: 6
Pages: 2683-94
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Publication
9495343 | J:46134
First Author: Withers DJ
Year: 1998
Journal: Nature
Title: Disruption of IRS-2 causes type 2 diabetes in mice.
Volume: 391
Issue: 6670
Pages: 900-4
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Publication
12502742 | J:80976
First Author: Laustsen PG
Year: 2002
Journal: Genes Dev
Title: Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice.
Volume: 16
Issue: 24
Pages: 3213-22
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Publication
16105663 | J:100642
First Author: Zhou H
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action.
Volume: 335
Issue: 3
Pages: 937-42
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Publication
12810606 | J:99746
First Author: Kubota T
Year: 2003
Journal: Circulation
Title: Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.
Volume: 107
Issue: 24
Pages: 3073-80
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Publication
11078455 | J:65485
First Author: Kubota N
Year: 2000
Journal: Diabetes
Title: Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Volume: 49
Issue: 11
Pages: 1880-9
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Publication
11259600 | J:68004
First Author: Miki H
Year: 2001
Journal: Mol Cell Biol
Title: Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.
Volume: 21
Issue: 7
Pages: 2521-32
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Publication
11546755 | J:132899
First Author: Tobe K
Year: 2001
Journal: J Biol Chem
Title: Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.
Volume: 276
Issue: 42
Pages: 38337-40
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Publication
14736890 | J:89532
First Author: Shimoaka T
Year: 2004
Journal: J Biol Chem
Title: Impairment of bone healing by insulin receptor substrate-1 deficiency.
Volume: 279
Issue: 15
Pages: 15314-22
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Publication
22688336 | J:208534
First Author: Wang Z
Year: 2012
Journal: Diabetes
Title: Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
Volume: 61
Issue: 8
Pages: 2134-45
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Publication
28003360 | J:240715
First Author: Xi G
Year: 2017
Journal: J Biol Chem
Title: Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.
Volume: 292
Issue: 5
Pages: 2009-2020
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Publication
21356519 | J:172259
First Author: Kubota T
Year: 2011
Journal: Cell Metab
Title: Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.
Volume: 13
Issue: 3
Pages: 294-307
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Publication
28190325 | J:273780
First Author: Tang CY
Year: 2017
Journal: Mol Cells
Title: IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33.
Volume: 40
Issue: 2
Pages: 123-132
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Publication
38505620 | J:346448
First Author: Yuan W
Year: 2024
Journal: Theranostics
Title: Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H(+)-ATPase V0d1 subunit.
Volume: 14
Issue: 5
Pages: 2246-2264
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Publication
20804756 | J:201303
First Author: Li Q
Year: 2010
Journal: FEBS Lett
Title: The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes.
Volume: 584
Issue: 19
Pages: 4145-50
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Publication
8631859 | J:33665
First Author: Sun XJ
Year: 1996
Journal: J Biol Chem
Title: The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation.
Volume: 271
Issue: 18
Pages: 10583-7
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Publication
10801879 | J:63655
First Author: Poltilove RM
Year: 2000
Journal: J Biol Chem
Title: Characterization of Drosophila insulin receptor substrate.
Volume: 275
Issue: 30
Pages: 23346-54
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Publication
8876252 | J:36649
First Author: Richards RG
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Estradiol stimulates tyrosine phosphorylation of the insulin-like growth factor-1 receptor and insulin receptor substrate-1 in the uterus.
Volume: 93
Issue: 21
Pages: 12002-7
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Publication
9565625 | J:47859
First Author: Richards RG
Year: 1998
Journal: J Biol Chem
Title: Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse.
Volume: 273
Issue: 19
Pages: 11962-9
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Publication
19560437 | J:154240
First Author: Zhou J
Year: 2009
Journal: Arch Biochem Biophys
Title: Bidirectional regulation of insulin receptor autophosphorylation and kinase activity by peroxynitrite.
Volume: 488
Issue: 1
Pages: 1-8
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Publication
24686304 | J:213650
 
First Author: Arnold SE
Year: 2014
Journal: Neurobiol Dis
Title: High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice.
Volume: 67
Pages: 79-87
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Publication
34537327 | J:318654
 
First Author: Ochiai T
Year: 2021
Journal: Neurobiol Dis
Title: Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.
Volume: 159
Pages: 105510
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Publication
11018022 | J:66427
First Author: Farhang-Fallah J
Year: 2000
Journal: J Biol Chem
Title: Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein.
Volume: 275
Issue: 51
Pages: 40492-7
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Publication
27739494 | J:265618
 
First Author: Liu T
Year: 2016
Journal: Sci Rep
Title: A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes.
Volume: 6
Pages: 35438
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Publication
15537637 | J:96157
First Author: Song HH
Year: 2005
Journal: J Biol Chem
Title: The loss of glypican-3 induces alterations in Wnt signaling.
Volume: 280
Issue: 3
Pages: 2116-25
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Publication
23401856 | J:203319
First Author: Koh A
Year: 2013
Journal: Mol Cell Biol
Title: C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy.
Volume: 33
Issue: 8
Pages: 1608-20
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Publication
23720771 | J:201792
First Author: Zhang J
Year: 2013
Journal: J Biol Chem
Title: Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
Volume: 288
Issue: 28
Pages: 20692-701
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Publication
15805118 | J:98746
First Author: Sugita H
Year: 2005
Journal: J Biol Chem
Title: Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells.
Volume: 280
Issue: 14
Pages: 14203-11
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Publication
22199371 | J:195961
First Author: Galkina EV
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1.
Volume: 32
Issue: 2
Pages: 247-56
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Publication
10642598 | J:59431
First Author: Kido Y
Year: 2000
Journal: J Clin Invest
Title: Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
Volume: 105
Issue: 2
Pages: 199-205
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Publication
17545163 | J:124807
First Author: Xue B
Year: 2007
Journal: J Biol Chem
Title: Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
Volume: 282
Issue: 33
Pages: 23829-40
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Publication
9844629 | J:51266
First Author: Brüning JC
Year: 1998
Journal: Mol Cell
Title: A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.
Volume: 2
Issue: 5
Pages: 559-69
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Publication
30532187 | J:269453
First Author: Kalvisa A
Year: 2018
Journal: PLoS Biol
Title: Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.
Volume: 16
Issue: 12
Pages: e2006249
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Publication
20103709 | J:164327
First Author: Georgia S
Year: 2010
Journal: Diabetes
Title: Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents.
Volume: 59
Issue: 4
Pages: 987-96
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8649419 | J:110842
First Author: Yamauchi T
Year: 1996
Journal: Mol Cell Biol
Title: Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
Volume: 16
Issue: 6
Pages: 3074-84
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Publication
15372107 | J:92861
First Author: Kulkarni RN
Year: 2004
Journal: J Clin Invest
Title: PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.
Volume: 114
Issue: 6
Pages: 828-36
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Publication
17200721 | J:117446
First Author: Terauchi Y
Year: 2007
Journal: J Clin Invest
Title: Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
Volume: 117
Issue: 1
Pages: 246-57
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Publication
7534300 | J:23766
First Author: Tobe K
Year: 1995
Journal: J Biol Chem
Title: Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.
Volume: 270
Issue: 11
Pages: 5698-701
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Publication
23940800 | J:205902
First Author: Tao R
Year: 2013
Journal: PLoS One
Title: Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.
Volume: 8
Issue: 8
Pages: e71997
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14684612 | J:88697
First Author: Cariou B
Year: 2004
Journal: Endocrinology
Title: Cellular and molecular mechanisms of adipose tissue plasticity in muscle insulin receptor knockout mice.
Volume: 145
Issue: 4
Pages: 1926-32
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Publication
12483226 | J:81182
First Author: Holzenberger M
Year: 2003
Journal: Nature
Title: IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
Volume: 421
Issue: 6919
Pages: 182-7
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14733908 | J:87936
First Author: Le HT
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha.
Volume: 314
Issue: 2
Pages: 321-9
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Publication
19542202 | J:154405
First Author: Morris DL
Year: 2009
Journal: Diabetes
Title: SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.
Volume: 58
Issue: 9
Pages: 2039-47
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Publication
25569103 | J:235113
 
First Author: Liu L
Year: 2015
Journal: Cell Death Dis
Title: Tamoxifen reduces fat mass by boosting reactive oxygen species.
Volume: 6
Pages: e1586
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Publication
19066218 | J:142666
First Author: Choi CS
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.
Volume: 105
Issue: 50
Pages: 19926-31
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8776723 | J:327403
First Author: Dey BR
Year: 1996
Journal: Mol Endocrinol
Title: Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.
Volume: 10
Issue: 6
Pages: 631-41
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Publication
9813005 | J:230404
First Author: Burks DJ
Year: 1998
Journal: J Biol Chem
Title: IRS pleckstrin homology domains bind to acidic motifs in proteins.
Volume: 273
Issue: 47
Pages: 31061-7
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14579029 | J:87110
First Author: Gual P
Year: 2003
Journal: Diabetologia
Title: MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.
Volume: 46
Issue: 11
Pages: 1532-42
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9729467 | J:85284
 
First Author: Sorokin A
Year: 1998
Journal: Biochem J
Title: Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1.
Volume: 334 ( Pt 3)
Pages: 595-600
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Publication
12878164 | J:84783
First Author: Tu X
Year: 2003
Journal: Exp Cell Res
Title: Intracellular redistribution of nuclear and nucleolar proteins during differentiation of 32D murine hemopoietic cells.
Volume: 288
Issue: 1
Pages: 119-30
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Publication
18285345 | J:145810
First Author: Waraich RS
Year: 2008
Journal: J Biol Chem
Title: Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells.
Volume: 283
Issue: 17
Pages: 11226-33
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Publication
17965023 | J:135557
First Author: Hakuno F
Year: 2007
Journal: J Biol Chem
Title: 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.
Volume: 282
Issue: 52
Pages: 37747-58
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Publication
23142081 | J:193983
First Author: Kim SJ
Year: 2012
Journal: Mol Cell
Title: mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
Volume: 48
Issue: 6
Pages: 875-87
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10417963 | J:57354
First Author: Accili D
Year: 1999
Journal: J Pediatr Endocrinol Metab
Title: Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.
Volume: 12
Issue: 4
Pages: 475-85
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Publication
14559999 | J:86242
First Author: Trojanek J
Year: 2003
Journal: Mol Cell Biol
Title: Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.
Volume: 23
Issue: 21
Pages: 7510-24
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Publication
15967802 | J:101044
First Author: Chen J
Year: 2005
Journal: J Biol Chem
Title: Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin.
Volume: 280
Issue: 33
Pages: 29912-20
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Publication
12679424 | J:131478
First Author: Esposito DL
Year: 2003
Journal: J Clin Endocrinol Metab
Title: A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.
Volume: 88
Issue: 4
Pages: 1468-75
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Publication
19273608 | J:149157
First Author: Assmann A
Year: 2009
Journal: Mol Cell Biol
Title: Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.
Volume: 29
Issue: 11
Pages: 3219-28
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