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Search results 101 to 200 out of 285 for Irs2

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Type Details Score
Publication
15028732 | J:90738
First Author: Suzuki R
Year: 2004
Journal: J Biol Chem
Title: Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice.
Volume: 279
Issue: 24
Pages: 25039-49
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Publication
31700039 | J:323513
First Author: Ito Y
Year: 2019
Journal: Sci Rep
Title: The beneficial effects of a muscarinic agonist on pancreatic β-cells.
Volume: 9
Issue: 1
Pages: 16180
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Publication
17460360 | J:122832
First Author: Hashimoto H
Year: 2007
Journal: Exp Anim
Title: Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable.
Volume: 56
Issue: 2
Pages: 149-54
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Publication
27525648 | J:237039
First Author: Sato H
Year: 2016
Journal: Diabetologia
Title: Anagliptin increases insulin-induced skeletal muscle glucose uptake via an NO-dependent mechanism in mice.
Volume: 59
Issue: 11
Pages: 2426-2434
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Publication
19920186 | J:155053
First Author: Mardilovich K
Year: 2009
Journal: Cancer Res
Title: Hypoxia regulates insulin receptor substrate-2 expression to promote breast carcinoma cell survival and invasion.
Volume: 69
Issue: 23
Pages: 8894-901
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Publication
15509777 | J:94107
First Author: Nagle JA
Year: 2004
Journal: Mol Cell Biol
Title: Involvement of insulin receptor substrate 2 in mammary tumor metastasis.
Volume: 24
Issue: 22
Pages: 9726-35
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Publication
8995447 | J:38109
First Author: Welham MJ
Year: 1997
Journal: J Biol Chem
Title: Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells.
Volume: 272
Issue: 2
Pages: 1377-81
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Publication
16127164 | J:100681
First Author: Boissan M
Year: 2005
Journal: Am J Pathol
Title: Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma.
Volume: 167
Issue: 3
Pages: 869-77
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Publication
10829031 | J:115334
First Author: Fasshauer M
Year: 2000
Journal: J Biol Chem
Title: Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes.
Volume: 275
Issue: 33
Pages: 25494-501
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Publication
20547979 | J:169348
First Author: Gurevitch D
Year: 2010
Journal: Diabetes
Title: Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress.
Volume: 59
Issue: 9
Pages: 2188-97
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Publication
21940781 | J:189475
First Author: Demozay D
Year: 2011
Journal: Diabetes
Title: Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet β-cells.
Volume: 60
Issue: 11
Pages: 2892-902
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Publication
22912850 | J:189973
First Author: Neukamm SS
Year: 2012
Journal: PLoS One
Title: Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573.
Volume: 7
Issue: 8
Pages: e43296
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Publication
- | J:66046
   
First Author: Xu G
Year: 1998
Journal: GenBank Submission
Title: Mus musculus insulin receptor substrate-2 (Irs2) gene, partial cds
Pages: AF090738
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Publication
14755338 | J:87590
First Author: Asilmaz E
Year: 2004
Journal: J Clin Invest
Title: Site and mechanism of leptin action in a rodent form of congenital lipodystrophy.
Volume: 113
Issue: 3
Pages: 414-24
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Publication
28833887 | J:251043
First Author: Chirivella L
Year: 2017
Journal: Stem Cells
Title: Cyclin-Dependent Kinase 4 Regulates Adult Neural Stem Cell Proliferation and Differentiation in Response to Insulin.
Volume: 35
Issue: 12
Pages: 2403-2416
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Publication
23702782 | J:214039
First Author: Arroba AI
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice.
Volume: 54
Issue: 6
Pages: 4215-25
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Publication
24517226 | J:210484
First Author: Togashi Y
Year: 2014
Journal: Endocrinology
Title: β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.
Volume: 155
Issue: 5
Pages: 1643-52
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Publication
24712877 | J:213137
First Author: Shirakawa J
Year: 2014
Journal: Endocrinology
Title: Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β-cell functions, and β-cell proliferation in male mice.
Volume: 155
Issue: 6
Pages: 2102-11
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Publication
16774126 | J:145064
First Author: Hashimoto H
Year: 2006
Journal: Comp Med
Title: Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2.
Volume: 56
Issue: 3
Pages: 176-87
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Publication
15550388 | J:96977
First Author: Suzuki R
Year: 2005
Journal: J Biol Chem
Title: Expression of DGAT2 in white adipose tissue is regulated by central leptin action.
Volume: 280
Issue: 5
Pages: 3331-7
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Publication
7675087 | J:38317
First Author: Sun XJ
Year: 1995
Journal: Nature
Title: Role of IRS-2 in insulin and cytokine signalling.
Volume: 377
Issue: 6545
Pages: 173-7
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Publication
17901049 | J:128457
First Author: Zhang J
Year: 2007
Journal: J Biol Chem
Title: The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation.
Volume: 282
Issue: 47
Pages: 34356-64
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Publication
26022372 | J:233930
First Author: Vinué Á
Year: 2015
Journal: Biochim Biophys Acta
Title: Ink4/Arf locus restores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling.
Volume: 1852
Issue: 9
Pages: 1729-42
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Publication
12746333 | J:83689
First Author: Lee AV
Year: 2003
Journal: Endocrinology
Title: Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.
Volume: 144
Issue: 6
Pages: 2683-94
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Publication
17928362 | J:134916
First Author: Selman C
Year: 2008
Journal: FASEB J
Title: Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
Volume: 22
Issue: 3
Pages: 807-18
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9495343 | J:46134
First Author: Withers DJ
Year: 1998
Journal: Nature
Title: Disruption of IRS-2 causes type 2 diabetes in mice.
Volume: 391
Issue: 6670
Pages: 900-4
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Publication
12810606 | J:99746
First Author: Kubota T
Year: 2003
Journal: Circulation
Title: Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.
Volume: 107
Issue: 24
Pages: 3073-80
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Publication
11078455 | J:65485
First Author: Kubota N
Year: 2000
Journal: Diabetes
Title: Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Volume: 49
Issue: 11
Pages: 1880-9
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Publication
11259600 | J:68004
First Author: Miki H
Year: 2001
Journal: Mol Cell Biol
Title: Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.
Volume: 21
Issue: 7
Pages: 2521-32
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Publication
11546755 | J:132899
First Author: Tobe K
Year: 2001
Journal: J Biol Chem
Title: Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.
Volume: 276
Issue: 42
Pages: 38337-40
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Publication
14736890 | J:89532
First Author: Shimoaka T
Year: 2004
Journal: J Biol Chem
Title: Impairment of bone healing by insulin receptor substrate-1 deficiency.
Volume: 279
Issue: 15
Pages: 15314-22
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Publication
22688336 | J:208534
First Author: Wang Z
Year: 2012
Journal: Diabetes
Title: Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
Volume: 61
Issue: 8
Pages: 2134-45
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Publication
28003360 | J:240715
First Author: Xi G
Year: 2017
Journal: J Biol Chem
Title: Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation.
Volume: 292
Issue: 5
Pages: 2009-2020
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Publication
28190325 | J:273780
First Author: Tang CY
Year: 2017
Journal: Mol Cells
Title: IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33.
Volume: 40
Issue: 2
Pages: 123-132
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Publication
10801879 | J:63655
First Author: Poltilove RM
Year: 2000
Journal: J Biol Chem
Title: Characterization of Drosophila insulin receptor substrate.
Volume: 275
Issue: 30
Pages: 23346-54
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Publication
34537327 | J:318654
 
First Author: Ochiai T
Year: 2021
Journal: Neurobiol Dis
Title: Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.
Volume: 159
Pages: 105510
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Publication
18288891 | J:135659
First Author: Tanabe K
Year: 2008
Journal: PLoS Biol
Title: Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
Volume: 6
Issue: 2
Pages: e37
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Publication
11018022 | J:66427
First Author: Farhang-Fallah J
Year: 2000
Journal: J Biol Chem
Title: Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein.
Volume: 275
Issue: 51
Pages: 40492-7
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Publication
17636024 | J:125126
First Author: Podcheko A
Year: 2007
Journal: Mol Cell Biol
Title: Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival.
Volume: 27
Issue: 18
Pages: 6484-96
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Publication
10949029 | J:63895
First Author: Shimomura I
Year: 2000
Journal: Mol Cell
Title: Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice.
Volume: 6
Issue: 1
Pages: 77-86
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Publication
16750510 | J:110785
First Author: Sobel BE
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Insulin resistance increases PAI-1 in the heart.
Volume: 346
Issue: 1
Pages: 102-7
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10642598 | J:59431
First Author: Kido Y
Year: 2000
Journal: J Clin Invest
Title: Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
Volume: 105
Issue: 2
Pages: 199-205
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Publication
30532187 | J:269453
First Author: Kalvisa A
Year: 2018
Journal: PLoS Biol
Title: Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver.
Volume: 16
Issue: 12
Pages: e2006249
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8649419 | J:110842
First Author: Yamauchi T
Year: 1996
Journal: Mol Cell Biol
Title: Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
Volume: 16
Issue: 6
Pages: 3074-84
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7534300 | J:23766
First Author: Tobe K
Year: 1995
Journal: J Biol Chem
Title: Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.
Volume: 270
Issue: 11
Pages: 5698-701
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Publication
33761350 | J:304286
First Author: Stöhr O
Year: 2021
Journal: Cell Rep
Title: FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance.
Volume: 34
Issue: 12
Pages: 108893
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Publication
16154098 | J:129682
First Author: Kitamura YI
Year: 2005
Journal: Cell Metab
Title: FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Volume: 2
Issue: 3
Pages: 153-63
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Publication
22210743 | J:182437
First Author: Burgos-Ramos E
Year: 2012
Journal: Endocrinology
Title: Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.
Volume: 153
Issue: 3
Pages: 1129-40
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Publication
23940800 | J:205902
First Author: Tao R
Year: 2013
Journal: PLoS One
Title: Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes.
Volume: 8
Issue: 8
Pages: e71997
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Publication
15821749 | J:98318
First Author: Bard-Chapeau EA
Year: 2005
Journal: Nat Med
Title: Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action.
Volume: 11
Issue: 5
Pages: 567-71
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Publication
12869553 | J:128796
First Author: Suzuki R
Year: 2003
Journal: J Biol Chem
Title: Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
Volume: 278
Issue: 44
Pages: 43691-8
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Publication
14733908 | J:87936
First Author: Le HT
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha.
Volume: 314
Issue: 2
Pages: 321-9
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19542202 | J:154405
First Author: Morris DL
Year: 2009
Journal: Diabetes
Title: SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.
Volume: 58
Issue: 9
Pages: 2039-47
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25569103 | J:235113
 
First Author: Liu L
Year: 2015
Journal: Cell Death Dis
Title: Tamoxifen reduces fat mass by boosting reactive oxygen species.
Volume: 6
Pages: e1586
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9813005 | J:230404
First Author: Burks DJ
Year: 1998
Journal: J Biol Chem
Title: IRS pleckstrin homology domains bind to acidic motifs in proteins.
Volume: 273
Issue: 47
Pages: 31061-7
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9729467 | J:85284
 
First Author: Sorokin A
Year: 1998
Journal: Biochem J
Title: Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1.
Volume: 334 ( Pt 3)
Pages: 595-600
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17965023 | J:135557
First Author: Hakuno F
Year: 2007
Journal: J Biol Chem
Title: 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.
Volume: 282
Issue: 52
Pages: 37747-58
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9013772 | J:38301
First Author: Sun XJ
Year: 1997
Journal: Mol Endocrinol
Title: The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.
Volume: 11
Issue: 2
Pages: 251-62
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10417963 | J:57354
First Author: Accili D
Year: 1999
Journal: J Pediatr Endocrinol Metab
Title: Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.
Volume: 12
Issue: 4
Pages: 475-85
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19273608 | J:149157
First Author: Assmann A
Year: 2009
Journal: Mol Cell Biol
Title: Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2.
Volume: 29
Issue: 11
Pages: 3219-28
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21628386 | J:174867
First Author: Sun Z
Year: 2011
Journal: Endocrinology
Title: Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.
Volume: 152
Issue: 8
Pages: 3233-45
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12219087 | J:79560
First Author: Nakae J
Year: 2002
Journal: Nat Genet
Title: Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.
Volume: 32
Issue: 2
Pages: 245-53
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16625210 | J:109024
First Author: Foukas LC
Year: 2006
Journal: Nature
Title: Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.
Volume: 441
Issue: 7091
Pages: 366-70
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29028997 | J:251906
First Author: Kyohara M
Year: 2017
Journal: Endocrinology
Title: Serum Quantitative Proteomic Analysis Reveals Soluble EGFR To Be a Marker of Insulin Resistance in Male Mice and Humans.
Volume: 158
Issue: 12
Pages: 4152-4164
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15685168 | J:96047
First Author: Uchida T
Year: 2005
Journal: Nat Med
Title: Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice.
Volume: 11
Issue: 2
Pages: 175-82
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16327801 | J:104468
First Author: Nakagawa Y
Year: 2006
Journal: Nat Med
Title: TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
Volume: 12
Issue: 1
Pages: 107-13
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26116826 | J:227036
 
First Author: Hirukawa H
Year: 2015
Journal: Mol Cell Endocrinol
Title: Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression.
Volume: 413
Pages: 49-60
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Publication
19838201 | J:154295
First Author: Cheng Z
Year: 2009
Journal: Nat Med
Title: Foxo1 integrates insulin signaling with mitochondrial function in the liver.
Volume: 15
Issue: 11
Pages: 1307-11
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12595588 | J:102264
First Author: Yamashita H
Year: 2003
Journal: Pediatr Res
Title: Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice.
Volume: 53
Issue: 3
Pages: 411-8
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21700708 | J:175918
First Author: Tanioka T
Year: 2011
Journal: J Biol Chem
Title: Inducible nitric-oxide synthase and nitric oxide donor decrease insulin receptor substrate-2 protein expression by promoting proteasome-dependent degradation in pancreatic beta-cells: involvement of glycogen synthase kinase-3beta.
Volume: 286
Issue: 33
Pages: 29388-96
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Publication
37202506 | J:337759
First Author: Yang W
Year: 2023
Journal: Diabetologia
Title: Hepatic p38α MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice.
Volume: 66
Issue: 7
Pages: 1322-1339
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Publication
23801577 | J:208951
First Author: Shirakawa J
Year: 2013
Journal: Diabetes
Title: Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic β-cells.
Volume: 62
Issue: 10
Pages: 3448-58
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Publication
28630133 | J:245081
First Author: Sasaki M
Year: 2017
Journal: Diabetes
Title: Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney.
Volume: 66
Issue: 9
Pages: 2339-2350
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9399964 | J:44906
First Author: Kerouz NJ
Year: 1997
Journal: J Clin Invest
Title: Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.
Volume: 100
Issue: 12
Pages: 3164-72
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Publication
12488434 | J:80826
First Author: Kitamura T
Year: 2002
Journal: J Clin Invest
Title: The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
Volume: 110
Issue: 12
Pages: 1839-47
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Publication
24677713 | J:229791
First Author: Fu Q
Year: 2014
Journal: Diabetes
Title: Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.
Volume: 63
Issue: 8
Pages: 2676-89
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Publication
36125265 | J:330376
First Author: Riehle C
Year: 2022
Journal: Mol Cell Biol
Title: Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart.
Volume: 42
Issue: 10
Pages: e0016322
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Publication
29610318 | J:261816
First Author: Xu H
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.
Volume: 115
Issue: 16
Pages: 4228-4233
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Publication
28710407 | J:250196
First Author: Sakurai Y
Year: 2017
Journal: Sci Rep
Title: Role of insulin receptor substrates in the progression of hepatocellular carcinoma.
Volume: 7
Issue: 1
Pages: 5387
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Publication
21081708 | J:172321
First Author: Wei D
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1.
Volume: 300
Issue: 2
Pages: E312-20
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Publication
16180138 | J:103242
First Author: Rance KA
Year: 2005
Journal: Mamm Genome
Title: A paternally imprinted QTL for mature body mass on mouse chromosome 8.
Volume: 16
Issue: 8
Pages: 567-77
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Publication
11375348 | J:107119
First Author: Tsuji Y
Year: 2001
Journal: Diabetes
Title: Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice.
Volume: 50
Issue: 6
Pages: 1455-63
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Publication
12783867 | J:85997
First Author: Deng Y
Year: 2003
Journal: J Biol Chem
Title: Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.
Volume: 278
Issue: 41
Pages: 39311-22
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Publication
14966273 | J:88179
First Author: Tseng YH
Year: 2004
Journal: Mol Cell Biol
Title: Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Volume: 24
Issue: 5
Pages: 1918-29
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Publication
15581362 | J:94676
First Author: Miura A
Year: 2004
Journal: Biochemistry
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