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Search results 13901 to 14000 out of 18692 for Ca1

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Category: Publication
Type Details Score
Publication
First Author: Liu Z
Year: 2012
Journal: Dev Dyn
Title: In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.
Volume: 241
Issue: 4
Pages: 684-96
Publication
First Author: Wang B
Year: 2016
Journal: Mol Reprod Dev
Title: RFX1 maintains testis cord integrity by regulating the expression of Itga6 in male mouse embryos.
Volume: 83
Issue: 7
Pages: 606-14
Publication
First Author: Cunningham CL
Year: 2011
Journal: Hum Mol Genet
Title: Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development.
Volume: 20
Issue: 1
Pages: 64-79
Publication
First Author: Bi Z
Year: 2022
Journal: Natl Sci Rev
Title: Development and transdifferentiation into inner hair cells require Tbx2.
Volume: 9
Issue: 12
Pages: nwac156
Publication
First Author: Kadowaki M
Year: 2007
Journal: Dev Biol
Title: N-cadherin mediates cortical organization in the mouse brain.
Volume: 304
Issue: 1
Pages: 22-33
Publication
First Author: Andersson L
Year: 2011
Journal: Endocrinology
Title: Role of EphA4 receptor signaling in thyroid development: regulation of folliculogenesis and propagation of the C-cell lineage.
Volume: 152
Issue: 3
Pages: 1154-64
Publication
First Author: Wang J
Year: 2011
Journal: Birth Defects Res A Clin Mol Teratol
Title: Defective sumoylation pathway directs congenital heart disease.
Volume: 91
Issue: 6
Pages: 468-76
Publication
First Author: Lathia JD
Year: 2008
Journal: J Neurosci
Title: Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation.
Volume: 28
Issue: 51
Pages: 13978-84
Publication
First Author: Belzil C
Year: 2014
Journal: Biol Open
Title: p600 regulates spindle orientation in apical neural progenitors and contributes to neurogenesis in the developing neocortex.
Volume: 3
Issue: 6
Pages: 475-85
Publication
First Author: Yuan W
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3.
Volume: 100
Issue: 9
Pages: 5217-22
Publication
First Author: Ishifune C
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Differentiation of CD11c+ CX3CR1+ cells in the small intestine requires Notch signaling.
Volume: 111
Issue: 16
Pages: 5986-91
Publication
First Author: Kos CH
Year: 2003
Journal: J Clin Invest
Title: Mice deficient in alpha-actinin-4 have severe glomerular disease.
Volume: 111
Issue: 11
Pages: 1683-90
Publication
First Author: Ohkawara B
Year: 2020
Journal: EMBO Rep
Title: CTGF/CCN2 facilitates LRP4-mediated formation of the embryonic neuromuscular junction.
Volume: 21
Issue: 8
Pages: e48462
Publication
First Author: Chauhan BK
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia.
Volume: 108
Issue: 45
Pages: 18289-94
Publication  
First Author: Leung C
Year: 2015
Journal: J Am Heart Assoc
Title: Rac1 Signaling Is Required for Anterior Second Heart Field Cellular Organization and Cardiac Outflow Tract Development.
Volume: 5
Issue: 1
Publication
First Author: Kumar S
Year: 2010
Journal: Dev Biol
Title: Retinoic acid signaling in perioptic mesenchyme represses Wnt signaling via induction of Pitx2 and Dkk2.
Volume: 340
Issue: 1
Pages: 67-74
Publication
First Author: Madaro L
Year: 2011
Journal: Mol Biol Cell
Title: PKCθ signaling is required for myoblast fusion by regulating the expression of caveolin-3 and β1D integrin upstream focal adhesion kinase.
Volume: 22
Issue: 8
Pages: 1409-19
Publication    
First Author: He Y
Year: 2021
Journal: Elife
Title: T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.
Volume: 10
Publication
First Author: Wasik AA
Year: 2012
Journal: Mol Biol Cell
Title: Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.
Volume: 23
Issue: 17
Pages: 3370-9
Publication
First Author: Schmidt H
Year: 2002
Journal: J Cell Biol
Title: cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons.
Volume: 159
Issue: 3
Pages: 489-98
Publication
First Author: Winkle CC
Year: 2016
Journal: J Neurosci
Title: Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory.
Volume: 36
Issue: 18
Pages: 4940-58
Publication
First Author: Zhang T
Year: 2023
Journal: Cell Rep
Title: Autophagy collaborates with apoptosis pathways to control oligodendrocyte number.
Volume: 42
Issue: 8
Pages: 112943
Publication
First Author: Kurtzeborn K
Year: 2022
Journal: BMC Biol
Title: Comparative whole-genome transcriptome analysis in renal cell populations reveals high tissue specificity of MAPK/ERK targets in embryonic kidney.
Volume: 20
Issue: 1
Pages: 112
Publication
First Author: Blakely BD
Year: 2013
Journal: Stem Cells Dev
Title: Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons.
Volume: 22
Issue: 15
Pages: 2132-44
Publication
First Author: Reppschläger K
Year: 2016
Journal: J Biol Chem
Title: TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.
Volume: 291
Issue: 43
Pages: 22427-22441
Publication
First Author: Diéguez-Hurtado R
Year: 2019
Journal: Nat Commun
Title: Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes.
Volume: 10
Issue: 1
Pages: 2817
Publication
First Author: Fan Z
Year: 2017
Journal: Nucleic Acids Res
Title: A class of circadian long non-coding RNAs mark enhancers modulating long-range circadian gene regulation.
Volume: 45
Issue: 10
Pages: 5720-5738
Publication  
First Author: Hand R
Year: 2011
Journal: Neural Dev
Title: Neurogenin2 regulates the initial axon guidance of cortical pyramidal neurons projecting medially to the corpus callosum.
Volume: 6
Pages: 30
Publication
First Author: Yazlovitskaya EM
Year: 2015
Journal: Mol Biol Cell
Title: Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt.
Volume: 26
Issue: 10
Pages: 1857-74
Publication
First Author: Meng Q
Year: 2014
Journal: Dev Biol
Title: Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.
Volume: 395
Issue: 1
Pages: 29-37
Publication
First Author: Meng Q
Year: 2018
Journal: Dev Biol
Title: Repression of MAP3K1 expression and JNK activity by canonical Wnt signaling.
Volume: 440
Issue: 2
Pages: 129-136
Publication
First Author: Lafuente MJ
Year: 2003
Journal: EMBO J
Title: Regulation of mature T lymphocyte proliferation and differentiation by Par-4.
Volume: 22
Issue: 18
Pages: 4689-98
Publication
First Author: Ademi H
Year: 2022
Journal: Cell Rep
Title: Deciphering the origins and fates of steroidogenic lineages in the mouse testis.
Volume: 39
Issue: 11
Pages: 110935
Publication
First Author: Shmelkov SV
Year: 2010
Journal: Nat Med
Title: Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice.
Volume: 16
Issue: 5
Pages: 598-602, 1p following 602
Publication
First Author: Amakawa Y
Year: 2015
Journal: Development
Title: A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.
Volume: 142
Issue: 24
Pages: 4299-308
Publication  
First Author: Chattopadhyay S
Year: 2013
Journal: MBio
Title: Inhibition of viral pathogenesis and promotion of the septic shock response to bacterial infection by IRF-3 are regulated by the acetylation and phosphorylation of its coactivators.
Volume: 4
Issue: 2
Publication
First Author: Marangoni F
Year: 2021
Journal: Cell
Title: Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop.
Volume: 184
Issue: 15
Pages: 3998-4015.e19
Publication
First Author: Naim E
Year: 2005
Journal: Kidney Int
Title: Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney.
Volume: 68
Issue: 3
Pages: 955-65
Publication
First Author: Cao M
Year: 2014
Journal: J Neurosci
Title: Upregulation of Parkin in endophilin mutant mice.
Volume: 34
Issue: 49
Pages: 16544-9
Publication
First Author: Williams ET
Year: 2018
Journal: Hum Mol Genet
Title: Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.
Volume: 27
Issue: 18
Pages: 3189-3205
Publication
First Author: Nayernia K
Year: 2003
Journal: J Biol Chem
Title: Inactivation of a testis-specific Lis1 transcript in mice prevents spermatid differentiation and causes male infertility.
Volume: 278
Issue: 48
Pages: 48377-85
Publication
First Author: Messina A
Year: 2011
Journal: Hum Mol Genet
Title: Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility.
Volume: 20
Issue: 24
Pages: 4759-74
Publication    
First Author: Dos-Santos Carvalho S
Year: 2020
Journal: Elife
Title: Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth.
Volume: 9
Publication
First Author: Penisson M
Year: 2022
Journal: Hum Mol Genet
Title: Lis1 mutation prevents basal radial glia-like cell production in the mouse.
Volume: 31
Issue: 6
Pages: 942-957
Publication
First Author: Mire E
Year: 2018
Journal: Curr Biol
Title: Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons.
Volume: 28
Issue: 11
Pages: 1768-1782.e4
Publication  
First Author: Greenman R
Year: 2015
Journal: Front Neurosci
Title: Non-cell autonomous and non-catalytic activities of ATX in the developing brain.
Volume: 9
Pages: 53
Publication
First Author: Szabo R
Year: 2007
Journal: Oncogene
Title: Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development.
Volume: 26
Issue: 11
Pages: 1546-56
Publication
First Author: Ramasamy SK
Year: 2014
Journal: Nature
Title: Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.
Volume: 507
Issue: 7492
Pages: 376-380
Publication
First Author: Nguyen C
Year: 2006
Journal: Scand J Immunol
Title: Sjögren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus.
Volume: 64
Issue: 3
Pages: 295-307
Publication  
First Author: Brischetto C
Year: 2021
Journal: Development
Title: NF-κB determines Paneth versus goblet cell fate decision in the small intestine.
Volume: 148
Issue: 21
Publication
First Author: Feng L
Year: 2016
Journal: J Cell Sci
Title: ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice.
Volume: 129
Issue: 11
Pages: 2202-12
Publication
First Author: Dailey-Krempel B
Year: 2023
Journal: Cell Rep
Title: A tug of war between DCC and ROBO1 signaling during commissural axon guidance.
Volume: 42
Issue: 5
Pages: 112455
Publication  
First Author: Fang L
Year: 2023
Journal: Front Neurosci
Title: TIMP3 promotes the maintenance of neural stem-progenitor cells in the mouse subventricular zone.
Volume: 17
Pages: 1149603
Publication
First Author: Hasegawa Y
Year: 2010
Journal: Acta Histochem Cytochem
Title: High expression of Pitx-2 in the ICAT-deficient metanephros leads to developmental arrest.
Volume: 43
Issue: 2
Pages: 51-9
Publication  
First Author: Wang C
Year: 2017
Journal: Nat Commun
Title: IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.
Volume: 8
Pages: 15508
Publication
First Author: Murtomaki A
Year: 2014
Journal: Development
Title: Notch signaling functions in lymphatic valve formation.
Volume: 141
Issue: 12
Pages: 2446-51
Publication  
First Author: Wazin F
Year: 2020
Journal: Exp Eye Res
Title: The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis.
Volume: 191
Pages: 107917
Publication
First Author: Lee GH
Year: 1995
Journal: Genetics
Title: Identification of hepatocarcinogen-resistance genes in DBA/2 mice.
Volume: 139
Issue: 1
Pages: 387-95
Publication
First Author: Chiba H
Year: 2008
Journal: Genesis
Title: De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes.
Volume: 46
Issue: 12
Pages: 768-74
Publication
First Author: Schwingshackl A
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.
Volume: 313
Issue: 6
Pages: L1030-L1046
Publication
First Author: Peyronnet R
Year: 2012
Journal: Cell Rep
Title: Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels.
Volume: 1
Issue: 3
Pages: 241-50
Publication
First Author: Dirkx E
Year: 2013
Journal: Nat Cell Biol
Title: Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure.
Volume: 15
Issue: 11
Pages: 1282-93
Publication
First Author: Kröcher T
Year: 2014
Journal: Development
Title: A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex.
Volume: 141
Issue: 15
Pages: 3022-32
Publication
First Author: Cheng A
Year: 2007
Journal: J Neurosci
Title: Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage.
Volume: 27
Issue: 14
Pages: 3722-33
Publication  
First Author: Santana-Varela S
Year: 2021
Journal: Wellcome Open Res
Title: Tools for analysis and conditional deletion of subsets of sensory neurons.
Volume: 6
Pages: 250
Publication  
First Author: Pook C
Year: 2020
Journal: Gene Expr Patterns
Title: Expression pattern of Nav2 in the murine CNS with development.
Volume: 35
Pages: 119099
Publication
First Author: Manukyan I
Year: 2010
Journal: J Cell Mol Med
Title: Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli.
Volume: 14
Issue: 6B
Pages: 1707-16
Publication
First Author: Ikeda S
Year: 2009
Journal: Mol Cell Biol
Title: MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes.
Volume: 29
Issue: 8
Pages: 2193-204
Publication
First Author: Li Y
Year: 2022
Journal: Cell Rep
Title: Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors.
Volume: 40
Issue: 9
Pages: 111289
Publication
First Author: Rama N
Year: 2012
Journal: J Biol Chem
Title: Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth.
Volume: 287
Issue: 35
Pages: 30014-23
Publication
First Author: Yu HM
Year: 2005
Journal: Development
Title: The role of Axin2 in calvarial morphogenesis and craniosynostosis.
Volume: 132
Issue: 8
Pages: 1995-2005
Publication
First Author: Gartz Hanson M
Year: 2015
Journal: Dev Biol
Title: Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.
Volume: 404
Issue: 2
Pages: 76-87
Publication
First Author: Marzban H
Year: 2008
Journal: Neuroscience
Title: A novel transverse expression domain in the mouse cerebellum revealed by a neurofilament-associated antigen.
Volume: 153
Issue: 4
Pages: 1190-201
Publication
First Author: Chakrabarti L
Year: 2007
Journal: J Neurosci
Title: Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome.
Volume: 27
Issue: 43
Pages: 11483-95
Publication
First Author: Flintoff-Dye NL
Year: 2005
Journal: Dev Dyn
Title: Role for the alpha7beta1 integrin in vascular development and integrity.
Volume: 234
Issue: 1
Pages: 11-21
Publication
First Author: Jones EA
Year: 2008
Journal: Development
Title: Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos.
Volume: 135
Issue: 14
Pages: 2479-88
Publication
First Author: Everett CA
Year: 2004
Journal: Reproduction
Title: Genetic influences on ovulation of primary oocytes in LT/Sv strain mice.
Volume: 128
Issue: 5
Pages: 565-71
Publication
First Author: Jain S
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Adaptor protein-3 produces synaptic vesicles that release phasic dopamine.
Volume: 120
Issue: 42
Pages: e2309843120
Publication
First Author: Li Y
Year: 2017
Journal: J Neurosci Res
Title: Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network.
Volume: 95
Issue: 10
Pages: 1951-1964
Publication
First Author: Conti MA
Year: 2004
Journal: J Biol Chem
Title: Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice.
Volume: 279
Issue: 40
Pages: 41263-6
Publication
First Author: Mou C
Year: 2008
Journal: Hum Mutat
Title: Enhanced ectodysplasin-A receptor (EDAR) signaling alters multiple fiber characteristics to produce the East Asian hair form.
Volume: 29
Issue: 12
Pages: 1405-11
Publication
First Author: Kitamoto T
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.
Volume: 331
Issue: 4
Pages: 1154-62
Publication
First Author: Traustadóttir GÁ
Year: 2016
Journal: Cell Signal
Title: Evidence of non-canonical NOTCH signaling: Delta-like 1 homolog (DLK1) directly interacts with the NOTCH1 receptor in mammals.
Volume: 28
Issue: 4
Pages: 246-54
Publication
First Author: Cho IH
Year: 2011
Journal: Exp Mol Med
Title: JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains.
Volume: 43
Issue: 8
Pages: 462-70
Publication
First Author: Qiao X
Year: 2018
Journal: J Am Soc Nephrol
Title: Redirecting TGF-β Signaling through the β-Catenin/Foxo Complex Prevents Kidney Fibrosis.
Volume: 29
Issue: 2
Pages: 557-570
Publication
First Author: Morikawa Y
Year: 2004
Journal: J Neurosci
Title: Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia.
Volume: 24
Issue: 8
Pages: 1941-7
Publication
First Author: Sola-Carvajal A
Year: 2019
Journal: J Invest Dermatol
Title: Accumulation of Progerin Affects the Symmetry of Cell Division and Is Associated with Impaired Wnt Signaling and the Mislocalization of Nuclear Envelope Proteins.
Volume: 139
Issue: 11
Pages: 2272-2280.e12
Publication
First Author: Bedford L
Year: 2005
Journal: Dev Biol
Title: Id4 is required for the correct timing of neural differentiation.
Volume: 280
Issue: 2
Pages: 386-95
Publication
First Author: Spieler D
Year: 2014
Journal: Genome Res
Title: Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
Volume: 24
Issue: 4
Pages: 592-603
Publication
First Author: Shooshtarizadeh P
Year: 2019
Journal: Nat Commun
Title: Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.
Volume: 10
Issue: 1
Pages: 1270
Publication
First Author: Huraskin D
Year: 2016
Journal: Development
Title: Wnt/β-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers.
Volume: 143
Issue: 17
Pages: 3128-42
Publication
First Author: Yu HM
Year: 2007
Journal: Mech Dev
Title: Impaired neural development caused by inducible expression of Axin in transgenic mice.
Volume: 124
Issue: 2
Pages: 146-56
Publication
First Author: Laub F
Year: 2006
Journal: Brain Res
Title: Mice without transcription factor KLF7 provide new insight into olfactory bulb development.
Volume: 1103
Issue: 1
Pages: 108-13
Publication
First Author: Hanson MG
Year: 2014
Journal: Dev Biol
Title: Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders.
Volume: 395
Issue: 1
Pages: 84-95
Publication
First Author: Bloch M
Year: 2012
Journal: Circ Res
Title: High-mobility group A1 protein: a new coregulator of peroxisome proliferator-activated receptor-γ-mediated transrepression in the vasculature.
Volume: 110
Issue: 3
Pages: 394-405
Publication
First Author: Yu G
Year: 2001
Journal: Brain Res Dev Brain Res
Title: Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins.
Volume: 130
Issue: 2
Pages: 217-30
Publication
First Author: Fan X
Year: 2022
Journal: Nat Commun
Title: Noradrenergic signaling mediates cortical early tagging and storage of remote memory.
Volume: 13
Issue: 1
Pages: 7623
Publication
First Author: Adiguzel E
Year: 2013
Journal: Matrix Biol
Title: Type VIII collagen signals via β1 integrin and RhoA to regulate MMP-2 expression and smooth muscle cell migration.
Volume: 32
Issue: 6
Pages: 332-41
Publication
First Author: Bejarano E
Year: 2012
Journal: Mol Biol Cell
Title: Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner.
Volume: 23
Issue: 11
Pages: 2156-69
Publication
First Author: Riley BE
Year: 2010
Journal: J Cell Biol
Title: Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.
Volume: 191
Issue: 3
Pages: 537-52