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Search results 1501 to 1600 out of 5246 for App

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Category: Publication
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Type Details Score
Publication
23202730 | J:194181
First Author: Ly PT
Year: 2013
Journal: J Clin Invest
Title: Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.
Volume: 123
Issue: 1
Pages: 224-35
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Publication
27576688 | J:237285
First Author: Qin X
Year: 2016
Journal: J Biol Chem
Title: Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain.
Volume: 291
Issue: 42
Pages: 22276-22287
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Publication
33311478 | J:306682
First Author: Wu Z
Year: 2020
Journal: Cell Death Dis
Title: Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice.
Volume: 11
Issue: 12
Pages: 1058
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Publication
23562443 | J:198537
First Author: Zou K
Year: 2013
Journal: Am J Pathol
Title: Aβ43 is the earliest-depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE.
Volume: 182
Issue: 6
Pages: 2322-31
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Publication
18926877 | J:143592
First Author: Sabbagh MN
Year: 2008
Journal: Neurosci Lett
Title: Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind).
Volume: 448
Issue: 2
Pages: 217-20
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Publication
39498012 | J:359220
First Author: Martínez-Drudis L
Year: 2024
Journal: Heliyon
Title: Pharmacological inhibition of PLK2 kinase activity mitigates cognitive decline but aggravates APP pathology in a sex-dependent manner in APP/PS1 mouse model of Alzheimer's disease.
Volume: 10
Issue: 20
Pages: e39571
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Publication
8846093 | J:30150
First Author: Yao J
Year: 1995
Journal: Brain Res
Title: Chronic elevation of S100 beta protein does not alter APP mRNA expression or promote beta-amyloid deposition in the brains of aging transgenic mice.
Volume: 702
Issue: 1-2
Pages: 32-6
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Publication
12667466 | J:132454
First Author: Rutten BP
Year: 2003
Journal: Neurobiol Dis
Title: No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment.
Volume: 12
Issue: 2
Pages: 110-20
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Publication
15951428 | J:99874
First Author: Mastrangelo P
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Volume: 102
Issue: 25
Pages: 8972-7
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Publication
31363064 | J:287771
First Author: Martínez-Mármol R
Year: 2019
Journal: J Neurosci
Title: p110δ PI3-Kinase Inhibition Perturbs APP and TNFα Trafficking, Reduces Plaque Burden, Dampens Neuroinflammation, and Prevents Cognitive Decline in an Alzheimer's Disease Mouse Model.
Volume: 39
Issue: 40
Pages: 7976-7991
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Publication
39315073 | J:359167
 
First Author: Li C
Year: 2024
Journal: Front Neurosci
Title: 8-weeks aerobic exercise ameliorates cognitive deficit and mitigates ferroptosis triggered by iron overload in the prefrontal cortex of APP (Swe)/PSEN (1dE9) mice through Xc(-)/GPx4 pathway.
Volume: 18
Pages: 1453582
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Publication
17071095 | J:134734
First Author: Brijbassi S
Year: 2007
Journal: Neurobiol Dis
Title: Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
Volume: 25
Issue: 2
Pages: 291-6
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Publication
37216506 | J:345103
First Author: Zhou GF
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
Volume: 120
Issue: 22
Pages: e2220148120
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Publication
24824215 | J:214328
First Author: Jiang H
Year: 2014
Journal: Hum Mol Genet
Title: Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.
Volume: 23
Issue: 18
Pages: 4906-18
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Publication
28597477 | J:272157
First Author: Liu Y
Year: 2017
Journal: CNS Neurosci Ther
Title: Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in APP (swe)/PS1 (ΔE9) mice.
Volume: 23
Issue: 7
Pages: 590-604
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Publication
20354142 | -
First Author: Okada H
Year: 2010
Journal: FASEB J
Title: Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.
Volume: 24
Issue: 8
Pages: 2783-94
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Publication
26299962 | J:265989
First Author: Barão S
Year: 2015
Journal: Cell Rep
Title: Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse.
Volume: 12
Issue: 9
Pages: 1367-76
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Publication
27179792 | J:237310
First Author: Miyagawa T
Year: 2016
Journal: Hum Mol Genet
Title: BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
Volume: 25
Issue: 14
Pages: 2948-2958
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Publication
18660751 | J:138995
First Author: Jonas MC
Year: 2008
Journal: EMBO Rep
Title: PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.
Volume: 9
Issue: 9
Pages: 916-22
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Publication
34375641 | J:351455
First Author: Perdigão C
Year: 2021
Journal: J Biol Chem
Title: Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling.
Volume: 297
Issue: 3
Pages: 101056
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Publication
25384422 | J:218214
First Author: Parr C
Year: 2015
Journal: FASEB J
Title: Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter.
Volume: 29
Issue: 2
Pages: 623-35
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Publication
29325091 | J:276403
First Author: Wang X
Year: 2018
Journal: J Mol Cell Biol
Title: α-secretase ADAM10 physically interacts with β-secretase BACE1 in neurons and regulates CHL1 proteolysis.
Volume: 10
Issue: 5
Pages: 411-422
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Publication
30524268 | J:275173
 
First Author: Lippi SLP
Year: 2018
Journal: Front Aging Neurosci
Title: A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology.
Volume: 10
Pages: 382
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Publication
18055549 | J:129196
First Author: Bolmont T
Year: 2007
Journal: Am J Pathol
Title: Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.
Volume: 171
Issue: 6
Pages: 2012-20
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Publication
26196079 | J:225495
 
First Author: Fujiwara N
Year: 2015
Journal: Exp Neurol
Title: Cellular and molecular mechanisms of the restoration of human APP transgenic mouse cognitive dysfunction after transplant of human iPS cell-derived neural cells.
Volume: 271
Pages: 423-31
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Publication
30803762 | J:291180
First Author: Quartey MO
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice.
Volume: 511
Issue: 2
Pages: 454-459
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Publication
28028177 | J:240707
First Author: Feng T
Year: 2017
Journal: J Biol Chem
Title: Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.
Volume: 292
Issue: 5
Pages: 1679-1690
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Publication
28869759 | J:257178
First Author: Saadipour K
Year: 2018
Journal: J Neurochem
Title: p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.
Volume: 144
Issue: 3
Pages: 302-317
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Publication
32913125 | J:348430
First Author: Mori T
Year: 2020
Journal: J Biol Chem
Title: Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice.
Volume: 295
Issue: 48
Pages: 16251-16266
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Publication
26296617 | J:227022
First Author: Lundgren JL
Year: 2015
Journal: J Neurochem
Title: ADAM10 and BACE1 are localized to synaptic vesicles.
Volume: 135
Issue: 3
Pages: 606-15
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Publication
27716410 | J:329588
First Author: Pigoni M
Year: 2016
Journal: Mol Neurodegener
Title: Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.
Volume: 11
Issue: 1
Pages: 67
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Publication
28481921 | J:245918
First Author: Fusco FB
Year: 2017
Journal: PLoS One
Title: Low-sodium diet induces atherogenesis regardless of lowering blood pressure in hypertensive hyperlipidemic mice.
Volume: 12
Issue: 5
Pages: e0177086
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Publication
38729241 | J:349438
 
First Author: Basu R
Year: 2024
Journal: Mol Metab
Title: Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs.
Volume: 84
Pages: 101951
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Publication
32943702 | J:296378
First Author: Silva LEF
Year: 2020
Journal: Sci Rep
Title: Th17/Treg imbalance in COPD development: suppressors of cytokine signaling and signal transducers and activators of transcription proteins.
Volume: 10
Issue: 1
Pages: 15287
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Publication
28159908 | J:239680
First Author: Ye X
Year: 2017
Journal: J Neurosci
Title: Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
Volume: 37
Issue: 10
Pages: 2639-2655
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18341989 | J:132937
First Author: Wen Y
Year: 2008
Journal: Neuron
Title: Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing.
Volume: 57
Issue: 5
Pages: 680-90
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Publication
24889041 | J:218077
First Author: Devi L
Year: 2014
Journal: Neurobiol Aging
Title: PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease.
Volume: 35
Issue: 10
Pages: 2272-81
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23507144 | J:202419
First Author: Barroso E
Year: 2013
Journal: Biochim Biophys Acta
Title: Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARβ/δ-null mice.
Volume: 1832
Issue: 8
Pages: 1241-8
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15364953 | J:337599
First Author: Kitazume S
Year: 2005
Journal: J Biol Chem
Title: In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase.
Volume: 280
Issue: 9
Pages: 8589-95
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Publication
29979789 | J:263821
First Author: Causevic M
Year: 2018
Journal: PLoS One
Title: BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.
Volume: 13
Issue: 7
Pages: e0200344
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28855330 | J:248926
First Author: Choi GE
Year: 2017
Journal: J Neurosci
Title: Membrane-Associated Effects of Glucocorticoid on BACE1 Upregulation and Aβ Generation: Involvement of Lipid Raft-Mediated CREB Activation.
Volume: 37
Issue: 35
Pages: 8459-8476
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Publication
26900752 | J:236654
First Author: Oliverio M
Year: 2016
Journal: Nat Cell Biol
Title: Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function.
Volume: 18
Issue: 3
Pages: 328-36
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Publication
19920078 | J:155566
First Author: Ono Y
Year: 2009
Journal: J Cell Sci
Title: Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner.
Volume: 122
Issue: Pt 24
Pages: 4427-38
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Publication
17400334 | J:140915
First Author: Ryman D
Year: 2008
Journal: Neurobiol Aging
Title: Genetic loci modulating amyloid-beta levels in a mouse model of Alzheimer's disease.
Volume: 29
Issue: 8
Pages: 1190-8
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Publication
39609418 | J:360697
First Author: Miskalis A
Year: 2024
Journal: Nat Commun
Title: SPLICER: a highly efficient base editing toolbox that enables in vivo therapeutic exon skipping.
Volume: 15
Issue: 1
Pages: 10354
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Publication
23639209 | J:211730
First Author: Subaiea GM
Year: 2013
Journal: Neurobiol Aging
Title: Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice.
Volume: 34
Issue: 10
Pages: 2421-30
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Publication
24462621 | J:215369
 
First Author: Adwan L
Year: 2014
Journal: Neuropharmacology
Title: Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers.
Volume: 79
Pages: 596-602
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Publication
16364896 | J:107571
First Author: Cirrito JR
Year: 2005
Journal: Neuron
Title: Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
Volume: 48
Issue: 6
Pages: 913-22
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Publication
36717226 | J:348868
First Author: Ma F
Year: 2023
Journal: J Neurosci
Title: The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment.
Volume: 43
Issue: 10
Pages: 1830-1844
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Publication
34302009 | J:359845
First Author: Nash A
Year: 2021
Journal: Sci Rep
Title: BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory.
Volume: 11
Issue: 1
Pages: 15084
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Publication
28111074 | -
First Author: Huang YA
Year: 2017
Journal: Cell
Title: ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion.
Volume: 168
Issue: 3
Pages: 427-441.e21
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Publication
28197073 | -
 
First Author: Canu N
Year: 2017
Journal: Front Mol Neurosci
Title: Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents.
Volume: 10
Pages: 15
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Publication
21538175 | J:173252
First Author: Mody N
Year: 2011
Journal: Diabetologia
Title: Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein.
Volume: 54
Issue: 8
Pages: 2143-51
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Publication
19737556 | J:153764
First Author: Bloch L
Year: 2009
Journal: FEBS Lett
Title: Klotho is a substrate for alpha-, beta- and gamma-secretase.
Volume: 583
Issue: 19
Pages: 3221-4
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19744962 | J:153970
First Author: Mitchell JC
Year: 2009
Journal: Hum Mol Genet
Title: X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
Volume: 18
Issue: 23
Pages: 4492-500
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23792428 | J:199150
First Author: Cheret C
Year: 2013
Journal: EMBO J
Title: Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
Volume: 32
Issue: 14
Pages: 2015-28
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Publication
29062914 | J:297213
 
First Author: Tosh JL
Year: 2017
Journal: Wellcome Open Res
Title: The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease.
Volume: 2
Pages: 84
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8744400 | J:100978
First Author: Neve RL
Year: 1996
Journal: Neurobiol Aging
Title: Transgenic mice expressing APP-C100 in the brain.
Volume: 17
Issue: 2
Pages: 191-203
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27707970 | J:235934
First Author: Fleming MS
Year: 2016
Journal: J Neurosci
Title: A RET-ER81-NRG1 Signaling Pathway Drives the Development of Pacinian Corpuscles.
Volume: 36
Issue: 40
Pages: 10337-10355
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Publication
1438289 | J:105050
First Author: Kammesheidt A
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.
Volume: 89
Issue: 22
Pages: 10857-61
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20453200 | J:164465
First Author: Liu M
Year: 2010
Journal: J Lipid Res
Title: PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.
Volume: 51
Issue: 9
Pages: 2611-8
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17332754 | J:119815
First Author: Araki Y
Year: 2007
Journal: EMBO J
Title: The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.
Volume: 26
Issue: 6
Pages: 1475-86
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23554170 | J:350547
First Author: Pierrot N
Year: 2013
Journal: EMBO Mol Med
Title: Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.
Volume: 5
Issue: 4
Pages: 608-25
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22836275 | J:186537
First Author: Walker KR
Year: 2012
Journal: J Neurosci
Title: Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
Volume: 32
Issue: 30
Pages: 10423-37
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Publication
25080588 | J:223172
First Author: Eisele YS
Year: 2014
Journal: J Neurosci
Title: Multiple factors contribute to the peripheral induction of cerebral β-amyloidosis.
Volume: 34
Issue: 31
Pages: 10264-73
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20696495 | J:188232
First Author: Wilkinson BL
Year: 2012
Journal: Neurobiol Aging
Title: Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease.
Volume: 33
Issue: 1
Pages: 197.e21-32
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Publication
29328926 | J:351690
First Author: Tse KH
Year: 2018
Journal: Alzheimers Dement
Title: DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer's disease and dementia.
Volume: 14
Issue: 5
Pages: 664-679
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Publication
33009641 | -
First Author: da Rocha JF
Year: 2021
Journal: Mol Neurobiol
Title: APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis.
Volume: 58
Issue: 2
Pages: 668-688
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29725016 | J:262986
First Author: Wang ZH
Year: 2018
Journal: Nat Commun
Title: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 1784
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Publication
16421297 | J:104514
First Author: Yang Y
Year: 2006
Journal: J Neurosci
Title: Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models.
Volume: 26
Issue: 3
Pages: 775-84
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22413000 | J:186926
First Author: Chen J
Year: 2012
Journal: PLoS One
Title: Glutamine acts as a neuroprotectant against DNA damage, beta-amyloid and H2O2-induced stress.
Volume: 7
Issue: 3
Pages: e33177
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Publication
31306446 | J:277701
First Author: Lee JS
Year: 2019
Journal: PLoS One
Title: Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice.
Volume: 14
Issue: 7
Pages: e0219691
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Publication
29078331 | J:254186
First Author: Andrew RJ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
Volume: 114
Issue: 45
Pages: E9665-E9674
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14717705 | J:97674
First Author: Culvenor JG
Year: 2004
Journal: Eur J Biochem
Title: Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
Volume: 271
Issue: 2
Pages: 375-85
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23504710 | J:199954
First Author: Sachse CC
Year: 2013
Journal: FASEB J
Title: BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.
Volume: 27
Issue: 6
Pages: 2458-67
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Publication
37867176 | J:358195
First Author: Iyaswamy A
Year: 2023
Journal: Signal Transduct Target Ther
Title: Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease.
Volume: 8
Issue: 1
Pages: 404
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Publication
27022623 | J:240236
 
First Author: Shen X
Year: 2016
Journal: eNeuro
Title: Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling.
Volume: 3
Issue: 1
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Publication
36001414 | J:351557
First Author: Sapkota D
Year: 2022
Journal: Brain
Title: Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain.
Volume: 145
Issue: 9
Pages: 2982-2990
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Publication
24694184 | J:285067
 
First Author: Guzmán EA
Year: 2014
Journal: Mol Neurodegener
Title: Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.
Volume: 9
Pages: 13
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Publication
26035870 | J:223383
First Author: Arbogast T
Year: 2015
Journal: Dis Model Mech
Title: Deletion of the App-Runx1 region in mice models human partial monosomy 21.
Volume: 8
Issue: 6
Pages: 623-34
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Publication
8576160 | -
First Author: Beher D
Year: 1996
Journal: J Biol Chem
Title: Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.
Volume: 271
Issue: 3
Pages: 1613-20
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Publication
8626304 | -
First Author: Sturr MG
Year: 1996
Journal: J Bacteriol
Title: Purification of a cytochrome bd terminal oxidase encoded by the Escherichia coli app locus from a delta cyo delta cyd strain complemented by genes from Bacillus firmus OF4.
Volume: 178
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