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Search results 1501 to 1600 out of 4474 for Kl

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Category: Publication
Type Details Score
Publication
First Author: Sokhadze G
Year: 2022
Journal: J Comp Neurol
Title: The organization of cholinergic projections in the visual thalamus of the mouse.
Volume: 530
Issue: 7
Pages: 1081-1098
Publication
First Author: Soto F
Year: 2013
Journal: J Neurosci
Title: NGL-2 regulates pathway-specific neurite growth and lamination, synapse formation, and signal transmission in the retina.
Volume: 33
Issue: 29
Pages: 11949-59
Publication
First Author: Huang X
Year: 2019
Journal: Nat Commun
Title: Neural mechanisms of contextual modulation in the retinal direction selective circuit.
Volume: 10
Issue: 1
Pages: 2431
Publication  
First Author: Sabbah S
Year: 2017
Journal: eNeuro
Title: A Cre Mouse Line for Probing Irradiance- and Direction-Encoding Retinal Networks.
Volume: 4
Issue: 2
Publication  
First Author: Dumoulin A
Year: 2024
Journal: Development
Title: A cell-autonomous role for primary cilium-mediated signaling in long-range commissural axon guidance.
Volume: 151
Issue: 17
Publication
First Author: Willaredt MA
Year: 2012
Journal: Cilia
Title: Multiple essential roles for primary cilia in heart development.
Volume: 1
Issue: 1
Pages: 23
Publication
First Author: Hargett SR
Year: 2015
Journal: Am J Physiol Endocrinol Metab
Title: Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice.
Volume: 309
Issue: 3
Pages: E233-45
Publication
First Author: Kawahara M
Year: 2009
Journal: J Immunol
Title: Analysis of the role of tripeptidyl peptidase II in MHC class I antigen presentation in vivo.
Volume: 183
Issue: 10
Pages: 6069-77
Publication
First Author: Strokin M
Year: 2012
Journal: Hum Mol Genet
Title: Severe disturbance in the Ca2+ signaling in astrocytes from mouse models of human infantile neuroaxonal dystrophy with mutated Pla2g6.
Volume: 21
Issue: 12
Pages: 2807-14
Publication
First Author: Qi Q
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability.
Volume: 112
Issue: 23
Pages: 7255-60
Publication  
First Author: Ash PE
Year: 2014
Journal: Brain Res
Title: Pathological stress granules in Alzheimer's disease.
Volume: 1584
Pages: 52-8
Publication
First Author: Spitler KM
Year: 2021
Journal: Sci Rep
Title: Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice.
Volume: 11
Issue: 1
Pages: 7873
Publication
First Author: Zuloaga DG
Year: 2014
Journal: J Comp Neurol
Title: Estrogen receptor β expression in the mouse forebrain: age and sex differences.
Volume: 522
Issue: 2
Pages: 358-71
Publication  
First Author: Lupfer CR
Year: 2017
Journal: J Virol
Title: Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8+ T Cell Function and Impaired Viral Clearance.
Volume: 91
Issue: 17
Publication
First Author: Martin GR
Year: 2019
Journal: Sci Rep
Title: Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice.
Volume: 9
Issue: 1
Pages: 14281
Publication
First Author: True C
Year: 2013
Journal: Endocrinology
Title: Cocaine- and amphetamine-regulated transcript is a potent stimulator of GnRH and kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in females.
Volume: 154
Issue: 8
Pages: 2821-32
Publication
First Author: Zeineldin M
Year: 2014
Journal: Carcinogenesis
Title: Nuclear adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice.
Volume: 35
Issue: 8
Pages: 1881-90
Publication
First Author: Buckels EJ
Year: 2022
Journal: Am J Physiol Endocrinol Metab
Title: Genetic ablation of the preptin-coding portion of Igf2 impairs pancreatic function in female mice.
Volume: 323
Issue: 6
Pages: E467-E479
Publication
First Author: Nguyen TM
Year: 2012
Journal: J Lipid Res
Title: Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation.
Volume: 53
Issue: 1
Pages: 95-104
Publication  
First Author: Zangari T
Year: 2021
Journal: mBio
Title: Type I Interferon Signaling Is a Common Factor Driving Streptococcus pneumoniae and Influenza A Virus Shedding and Transmission.
Volume: 12
Issue: 1
Publication
First Author: Lanjewar AL
Year: 2023
Journal: J Comp Neurol
Title: Subclass-specific expression patterns of MET receptor tyrosine kinase during development in medial prefrontal and visual cortices.
Volume: 531
Issue: 1
Pages: 132-148
Publication  
First Author: Lacombe J
Year: 2018
Journal: JCI Insight
Title: VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.
Volume: 3
Issue: 1
Publication
First Author: Tsang SW
Year: 2018
Journal: Genesis
Title: Generation and characterization of pathogenic Mab21l2(R51C) mouse model.
Volume: 56
Issue: 11-12
Pages: e23261
Publication
First Author: Caruana BT
Year: 2019
Journal: J Immunol
Title: Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function.
Volume: 202
Issue: 6
Pages: 1826-1832
Publication      
First Author: Robertson SJ
Year: 2021
Journal: bioRxiv
Title: Genetically diverse mouse models of SARS-COV-2 infection model clinical variation and cytokine responses in COVID-19.
Publication
First Author: Leist SR
Year: 2019
Journal: PLoS One
Title: Increasing the translation of mouse models of MERS coronavirus pathogenesis through kinetic hematological analysis.
Volume: 14
Issue: 7
Pages: e0220126
Publication
First Author: Bogerd AM
Year: 1990
Journal: Mol Endocrinol
Title: Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.
Volume: 4
Issue: 6
Pages: 845-50
Publication
First Author: Yadav VR
Year: 2016
Journal: Mol Cell Biochem
Title: Vascular endothelial over-expression of soluble epoxide hydrolase (Tie2-sEH) enhances adenosine A1 receptor-dependent contraction in mouse mesenteric arteries: role of ATP-sensitive K+ channels.
Volume: 422
Issue: 1-2
Pages: 197-206
Publication
First Author: Fraschilla I
Year: 2022
Journal: Cell Host Microbe
Title: Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease.
Volume: 30
Issue: 10
Pages: 1370-1381.e5
Publication
First Author: Li J
Year: 2013
Journal: Exp Cell Res
Title: Regulation of MEF2 transcriptional activity by calcineurin/mAKAP complexes.
Volume: 319
Issue: 4
Pages: 447-54
Publication
First Author: Black BL
Year: 1996
Journal: J Biol Chem
Title: Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.
Volume: 271
Issue: 43
Pages: 26659-63
Publication  
First Author: Fatima S
Year: 2015
Journal: Sci Rep
Title: Interactome of the negative regulator of nuclear import BRCA1-binding protein 2.
Volume: 5
Pages: 9459
Publication
First Author: Anthis NJ
Year: 2010
Journal: Structure
Title: Structural diversity in integrin/talin interactions.
Volume: 18
Issue: 12
Pages: 1654-66
Publication
First Author: Cooper CL
Year: 1994
Journal: J Immunol
Title: Limited expression of C/EBP family proteins during B lymphocyte development. Negative regulator Ig/EBP predominates early and activator NF-IL-6 is induced later.
Volume: 153
Issue: 11
Pages: 5049-58
Publication
First Author: Lee JY
Year: 2010
Journal: J Cell Biol
Title: Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy.
Volume: 189
Issue: 4
Pages: 671-9
Publication
First Author: Ikenoue T
Year: 2008
Journal: EMBO J
Title: Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.
Volume: 27
Issue: 14
Pages: 1919-31
Publication
First Author: Kim-Han JS
Year: 2001
Journal: J Neurochem
Title: BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production.
Volume: 79
Issue: 3
Pages: 658-68
Publication
First Author: Price-Schiavi SA
Year: 2000
Journal: Biochem J
Title: Cloning and characterization of the 5' flanking region of the sialomucin complex/rat Muc4 gene: promoter activity in cultured cells.
Volume: 349
Issue: Pt 2
Pages: 641-9
Publication
First Author: Mager DL
Year: 2001
Journal: Curr Biol
Title: Evolution of natural killer cell receptors: coexistence of functional Ly49 and KIR genes in baboons.
Volume: 11
Issue: 8
Pages: 626-30
Publication
First Author: Zervas M
Year: 2001
Journal: Curr Biol
Title: Critical role for glycosphingolipids in Niemann-Pick disease type C.
Volume: 11
Issue: 16
Pages: 1283-7
Publication
First Author: Weeks BH
Year: 2001
Journal: Cancer Res
Title: Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis.
Volume: 61
Issue: 20
Pages: 7435-43
Publication
First Author: Martinez G
Year: 2001
Journal: Exp Nephrol
Title: Expression of bone morphogenetic protein receptors in the developing mouse metanephros.
Volume: 9
Issue: 6
Pages: 372-9
Publication
First Author: Liu B
Year: 2002
Journal: Infect Immun
Title: Model of differential susceptibility to mucosal Burkholderia pseudomallei infection.
Volume: 70
Issue: 2
Pages: 504-11
Publication
First Author: Shimozato O
Year: 2002
Journal: J Immunol
Title: Impaired NK cell development in an IFN-gamma transgenic mouse: aberrantly expressed IFN-gamma enhances hematopoietic stem cell apoptosis and affects NK cell differentiation.
Volume: 168
Issue: 4
Pages: 1746-52
Publication
First Author: Lee S
Year: 2000
Journal: J Neurosci
Title: short stop is allelic to kakapo, and encodes rod-like cytoskeletal-associated proteins required for axon extension.
Volume: 20
Issue: 3
Pages: 1096-108
Publication
First Author: Caldwell JH
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses.
Volume: 97
Issue: 10
Pages: 5616-20
Publication
First Author: Leef M
Year: 2000
Journal: J Exp Med
Title: Protective immunity to Bordetella pertussis requires both B cells and CD4(+) T cells for key functions other than specific antibody production.
Volume: 191
Issue: 11
Pages: 1841-52
Publication
First Author: Yao GQ
Year: 2000
Journal: Endocrinology
Title: Nuclear factor-kappaB p50 is required for tumor necrosis factor-alpha-induced colony-stimulating factor-1 gene expression in osteoblasts.
Volume: 141
Issue: 8
Pages: 2914-22
Publication
First Author: Loh SH
Year: 2000
Journal: Differentiation
Title: Characterization of a zebrafish (Danio rerio) desmin cDNA: an early molecular marker of myogenesis.
Volume: 65
Issue: 5
Pages: 247-54
Publication
First Author: Hanley NA
Year: 2000
Journal: Mol Cell Endocrinol
Title: Steroidogenic factor 1 (SF-1) is essential for ovarian development and function.
Volume: 163
Issue: 1-2
Pages: 27-32
Publication
First Author: Reiser H
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Gene encoding T-cell-activating protein TAP maps to the Ly-6 locus.
Volume: 83
Issue: 9
Pages: 2954-8
Publication
First Author: Toth LE
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Region-specific expression of mouse homeobox genes in the embryonic mesoderm and central nervous system.
Volume: 84
Issue: 19
Pages: 6790-4
Publication
First Author: Wong M
Year: 1989
Journal: J Biol Chem
Title: The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.
Volume: 264
Issue: 22
Pages: 12867-71
Publication
First Author: Tennent BJ
Year: 1990
Journal: Am J Obstet Gynecol
Title: Ovarian granulosa cell tumorigenesis in SWR-derived F1 hybrid mice: preneoplastic follicular abnormality and malignant disease progression.
Volume: 163
Issue: 2
Pages: 625-34
Publication
First Author: Feldhaus AL
Year: 1992
Journal: Mol Cell Biol
Title: BLyF, a novel cell-type- and stage-specific regulator of the B-lymphocyte gene mb-1.
Volume: 12
Issue: 3
Pages: 1126-33
Publication
First Author: Paria BC
Year: 1992
Journal: Dev Biol
Title: Localization and binding of transforming growth factor-beta isoforms in mouse preimplantation embryos and in delayed and activated blastocysts.
Volume: 151
Issue: 1
Pages: 91-104
Publication
First Author: Shaw MK
Year: 1992
Journal: J Neuroimmunol
Title: A combination of adoptive transfer and antigenic challenge induces consistent murine experimental autoimmune encephalomyelitis in C57BL/6 mice and other reputed resistant strains.
Volume: 39
Issue: 1-2
Pages: 139-49
Publication
First Author: Vidard L
Year: 1992
Journal: Eur J Immunol
Title: Processing and presentation of ovalbumin in mice genetically selected for antibody response.
Volume: 22
Issue: 8
Pages: 2165-8
Publication
First Author: Milstone DS
Year: 1992
Journal: J Biol Chem
Title: An element regulating adrenal-specific steroid 21-hydroxylase expression is located within the slp gene.
Volume: 267
Issue: 30
Pages: 21924-7
Publication
First Author: McLain K
Year: 1992
Journal: Mech Dev
Title: Ectopic expression of Hox-2.3 induces craniofacial and skeletal malformations in transgenic mice.
Volume: 39
Issue: 1-2
Pages: 3-16
Publication
First Author: Zhu X
Year: 1994
Journal: J Biol Chem
Title: Interleukin-2-induced tyrosine phosphorylation of Shc proteins correlates with factor-dependent T cell proliferation.
Volume: 269
Issue: 8
Pages: 5518-22
Publication
First Author: Mauro VP
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Cell adhesion alters gene transcription in chicken embryo brain cells and mouse embryonal carcinoma cells.
Volume: 91
Issue: 7
Pages: 2868-72
Publication
First Author: Zheng CF
Year: 1994
Journal: Biochemistry
Title: Growth factor induced MEK activation is primarily mediated by an activator different from c-raf.
Volume: 33
Issue: 18
Pages: 5595-9
Publication
First Author: Shen WH
Year: 1994
Journal: Cell
Title: Nuclear receptor steroidogenic factor 1 regulates the müllerian inhibiting substance gene: a link to the sex determination cascade.
Volume: 77
Issue: 5
Pages: 651-61
Publication
First Author: Ikeda Y
Year: 1994
Journal: Mol Endocrinol
Title: Developmental expression of mouse steroidogenic factor-1, an essential regulator of the steroid hydroxylases.
Volume: 8
Issue: 5
Pages: 654-62
Publication
First Author: Bennett E
Year: 1994
Journal: J Neurochem
Title: Cloning and characterization of a cDNA encoding a novel fatty acid binding protein from rat brain.
Volume: 63
Issue: 5
Pages: 1616-24
Publication
First Author: Felipe A
Year: 1994
Journal: Am J Physiol
Title: Differential expression of Isk mRNAs in mouse tissue during development and pregnancy.
Volume: 267
Issue: 3 Pt 1
Pages: C700-5
Publication
First Author: Dragone LL
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Disregulation of leukosialin (CD43, Ly48, sialophorin) expression in the B-cell lineage of transgenic mice increases splenic B-cell number and survival.
Volume: 92
Issue: 2
Pages: 626-30
Publication
First Author: Bustelo XR
Year: 1995
Journal: Mol Cell Biol
Title: Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins.
Volume: 15
Issue: 3
Pages: 1324-32
Publication
First Author: Howard PC
Year: 1995
Journal: Chem Biol Interact
Title: Metabolism of 1-nitropyrene in mice: transport across the placenta and mammary tissues.
Volume: 95
Issue: 3
Pages: 309-25
Publication
First Author: Carreno BM
Year: 1995
Journal: J Immunol
Title: Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin association.
Volume: 154
Issue: 10
Pages: 5173-80
Publication
First Author: Shull JD
Year: 1995
Journal: Gene
Title: Sequence of the promoter region of the mouse gene encoding ornithine aminotransferase.
Volume: 162
Issue: 2
Pages: 275-7
Publication    
First Author: Ruddle FH
Year: 1994
Journal: Dev Suppl
Title: Gene loss and gain in the evolution of the vertebrates.
Pages: 155-61
Publication
First Author: Aplin HM
Year: 1995
Journal: Genomics
Title: Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21.
Volume: 30
Issue: 2
Pages: 347-9
Publication
First Author: Hannon K
Year: 1996
Journal: J Cell Biol
Title: Differentially expressed fibroblast growth factors regulate skeletal muscle development through autocrine and paracrine mechanisms.
Volume: 132
Issue: 6
Pages: 1151-9
Publication  
First Author: Pan J
Year: 1996
Journal: Biochem J
Title: Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation.
Volume: 314 ( Pt 3)
Pages: 889-94
Publication
First Author: Kaplan DL
Year: 1996
Journal: J Cell Physiol
Title: Tumor necrosis factor-alpha induces transcription of the colony-stimulating factor-1 gene in murine osteoblasts.
Volume: 168
Issue: 1
Pages: 199-208
Publication
First Author: Wong M
Year: 1996
Journal: J Mol Endocrinol
Title: Cloning and sequence analysis of the human gene encoding steroidogenic factor 1.
Volume: 17
Issue: 2
Pages: 139-47
Publication
First Author: Whitehead IP
Year: 1997
Journal: Biochim Biophys Acta
Title: Dbl family proteins.
Volume: 1332
Issue: 1
Pages: F1-23
Publication
First Author: Gorgas G
Year: 1997
Journal: Mech Ageing Dev
Title: Diminished activation of the MAP kinase pathway in CD3-stimulated T lymphocytes from old mice.
Volume: 94
Issue: 1-3
Pages: 71-83
Publication
First Author: Theodos CM
Year: 1997
Journal: Infect Immun
Title: Profiles of healing and nonhealing Cryptosporidium parvum infection in C57BL/6 mice with functional B and T lymphocytes: the extent of gamma interferon modulation determines the outcome of infection.
Volume: 65
Issue: 11
Pages: 4761-9
Publication
First Author: Graham M
Year: 1997
Journal: Nat Genet
Title: Overexpression of Agrt leads to obesity in transgenic mice.
Volume: 17
Issue: 3
Pages: 273-4
Publication
First Author: Caughey GH
Year: 1997
Journal: J Immunol
Title: Cloning and expression of the dog mast cell alpha-chymase gene.
Volume: 159
Issue: 9
Pages: 4367-75
Publication
First Author: Ranheim T
Year: 1997
Journal: Arterioscler Thromb Vasc Biol
Title: Interaction between BTBR and C57BL/6J genomes produces an insulin resistance syndrome in (BTBR x C57BL/6J) F1 mice.
Volume: 17
Issue: 11
Pages: 3286-93
Publication
First Author: Damon SE
Year: 1997
Journal: Exp Cell Res
Title: Developmental regulation of Mac25/insulin-like growth factor-binding protein-7 expression in skeletal myogenesis.
Volume: 237
Issue: 1
Pages: 192-5
Publication
First Author: Mandl S
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen.
Volume: 95
Issue: 14
Pages: 8216-21
Publication
First Author: Selinsky CL
Year: 1998
Journal: Immunology
Title: Multifaceted inhibition of anti-tumour immune mechanisms by soluble tumour necrosis factor receptor type I.
Volume: 94
Issue: 1
Pages: 88-93
Publication
First Author: Steed PM
Year: 1998
Journal: FASEB J
Title: Characterization of human PLD2 and the analysis of PLD isoform splice variants.
Volume: 12
Issue: 13
Pages: 1309-17
Publication
First Author: Beamer WG
Year: 1998
Journal: Toxicol Pathol
Title: Mouse model for malignant juvenile ovarian granulosa cell tumors.
Volume: 26
Issue: 5
Pages: 704-10
Publication
First Author: Owen-Schaub LB
Year: 1998
Journal: J Exp Med
Title: Fas and Fas ligand interactions suppress melanoma lung metastasis.
Volume: 188
Issue: 9
Pages: 1717-23
Publication
First Author: Heller LC
Year: 1999
Journal: J Biol Chem
Title: Transcriptional regulation of the Bmp2 gene. Retinoic acid induction in F9 embryonal carcinoma cells and Saccharomyces cerevisiae.
Volume: 274
Issue: 3
Pages: 1394-400
Publication
First Author: Phelan DR
Year: 1999
Journal: Mol Reprod Dev
Title: Expression of mixed lineage kinase 2 in germ cells of the testis.
Volume: 52
Issue: 2
Pages: 135-40
Publication
First Author: Moscatello KM
Year: 1999
Journal: Cell Immunol
Title: Effects of in utero alcohol exposure on B cell development in neonatal spleen and bone marrow.
Volume: 191
Issue: 2
Pages: 124-30
Publication
First Author: Russell HI
Year: 1999
Journal: Eur J Immunol
Title: Class II antigen processing defects in two H2d mouse cell lines are caused by point mutations in the H2-DMa gene.
Volume: 29
Issue: 3
Pages: 905-11
Publication
First Author: Luch A
Year: 1999
Journal: Cancer Lett
Title: Tumor-initiating activity of the (+)-(S,S)- and (-)-(R,R)- enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene in mouse skin.
Volume: 136
Issue: 2
Pages: 119-28
Publication
First Author: Gupta A
Year: 1999
Journal: J Cancer Res Clin Oncol
Title: Experimental induction of rhabdomyosarcoma in mice with fractionated doses of beta-irradiation.
Volume: 125
Issue: 5
Pages: 257-67
Publication
First Author: Herzog CR
Year: 1999
Journal: Mol Carcinog
Title: Cdkn2a encodes functional variation of p16INK4a but not p19ARF, which confers selection in mouse lung tumorigenesis.
Volume: 25
Issue: 2
Pages: 92-8
Publication
First Author: Liu Q
Year: 1999
Journal: J Comp Neurol
Title: R-cadherin expression in the developing and adult zebrafish visual system.
Volume: 410
Issue: 2
Pages: 303-19
Publication
First Author: Lee KF
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Early developing embryos affect the gene expression patterns in the mouse oviduct.
Volume: 292
Issue: 2
Pages: 564-70
Publication
First Author: Seril DN
Year: 2002
Journal: Carcinogenesis
Title: Inhibition of chronic ulcerative colitis-associated colorectal adenocarcinoma development in a murine model by N-acetylcysteine.
Volume: 23
Issue: 6
Pages: 993-1001